Akumulacija strižnih napetosti med transportom cepiva : magistrsko delo

Bertalanič, Jan

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Title:	Akumulacija strižnih napetosti med transportom cepiva : magistrsko delo
Authors:	ID Bertalanič, Jan (Author) ID Zadravec, Matej (Mentor) More about this mentor... ID Kamenik, Blaž (Comentor)
Files:	MAG_Bertalanic_Jan_2022.pdf (3,22 MB) MD5: 5534E48FD506FB4289E87C8C0D3545E2
Language:	Slovenian
Work type:	Master's thesis/paper
Typology:	2.09 - Master's Thesis
Organization:	FS - Faculty of Mechanical Engineering
Abstract:	V magistrski nalogi je bilo izvedeno modeliranje večfaznega toka na podlagi volumskih sil, ki delujejo na tekočine med gibanjem. V obeh simulacijah je bil cilj ugotoviti količino akumuliranih strižnih napetosti v tekočini. V prvi simulaciji smo ugotavljali količino akumuliranih strižnih napetosti v kapljevini, ko se ta giblje v viali na laboratorijskem instrumentu, natančneje orbitalnem mešalniku (angl. orbital shaker). V drugi simulaciji je bil cilj enak, vendar je bila viala in s tem tudi tekočini, ki se nahajata v njem, izpostavljena določenemu režimu gibanja. Gibanje je bilo skladno s spektrom gibanja vozila, ki je predpisan v transportnem standardu ISTA 3A. Simulacije smo izvedli s pomočjo programa ANSYS FLUENT. Za pridobitev ustreznih vhodnih podatkov glede gibanja v primeru zasledovanja gibanja med transportom je bilo potrebno izvesti pretvorbo protokola gibanja iz PSD (Power Spectral Density) v pospešek tekočine, ki smo jo izvedli s pomočjo programske in numerične platforme MATLAB.
Keywords:	biološka zdravila, razpad beljakovin, strižne napetosti, akumulacija strižnih napetosti, transport
Place of publishing:	Maribor
Place of performance:	Maribor
Publisher:	[J. Bertalanič]
Year of publishing:	2022
Number of pages:	1 spletni vir (1 datoteka PDF (XIII, 60 f.))
PID:	20.500.12556/DKUM-81941
UDC:	615.81:531.226(043.2)
COBISS.SI-ID:	151363587
Publication date in DKUM:	09.09.2022
Views:	914
Downloads:	84
Metadata:
Categories:	KTFMB - FS
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Licences

License:	CC BY 4.0, Creative Commons Attribution 4.0 International

Link:	http://creativecommons.org/licenses/by/4.0/
Description:	This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:	20.06.2022

Secondary language

Language:	English
Title:	Accumulation of shear stresses during vaccine transport
Abstract:	In the master's thesis, modeling of a multiphase flow was performed based on the volumetric forces acting on the fluids during motion. In both simulations, the goal was to determine the amount of accumulated shear stress in the fluid. In the first simulation, we determined the amount of accumulated shear stress in the fluid as it moved in a vial on a laboratory device, specifically an orbital shaker. In the second simulation, the target was the same, but the vial, and thus the fluids within them, were subjected to a specific type of motion. The motion corresponded to the range of motion of the vehicle prescribed in the ISTA 3A transportation standard. The simulations were performed using the program ANSYS FLUENT. In order to obtain the appropriate input data for the motion in the case of motion tracking during transportation, it was necessary to perform the conversion of the motion protocol from PSD (Power Spectral Density) to fluid acceleration, which was done with the MATLAB software and numerical platform.
Keywords:	biological drugs, protein degradation, shear stresses, shear stress accumulation, transport

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