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Title:Sinteza magnetnih nanodelcev za uporabo v biomedicini : diplomsko delo univerzitetnega študijskega programa I. stopnje
Authors:ID Turner, Karin (Author)
ID Ban, Irena (Mentor) More about this mentor... New window
ID Stergar, Janja (Comentor)
Files:.pdf UN_Turner_Karin_2023.pdf (3,94 MB)
MD5: 510D4089CDA5C76663D83B9081941C7D
 
Language:Slovenian
Work type:Bachelor thesis/paper
Typology:2.11 - Undergraduate Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:V sklopu diplomskega dela smo sintetizirali magnetne nanodelce z uporabo visokoenergetskega planetarnega mlina. Prah železa in bakra smo mleli v inertni in zračni atmosferi, pri čemer smo spreminjali čas mletja in sestavo vzorca. Namen diplomskega dela je bil raziskati ali lahko s pomočjo mletja sintetiziramo zlitino FeCu s Curiejevo temperaturo (T_C), ki bi bila znotraj terapevtskega območja za uporabo v magnetni hipertermiji (MH). Sintezo FeCu nanodelcev smo začeli z mletjem v zračni atmosferi. Spreminjali smo sestavo vzorca in podaljševali čas mletja. Vsem vzorcem smo s pomočjo modificirane termogravimetrične analize (TGA) izmerili T_C. Najboljši rezultat smo dobili po 25 urnem mletju vzorca s sestavo Fe_40 Cu_60, vendar so meritve T_C pokazale, da so v produktu prisotni železovi oksidi in nekaj nezreagiranega železa. Vzorec enake sestave mlet 20 h smo dodatno okarakterizirali z rentgensko praškovno difrakcijo (RTG), ki je potrdila, da med mletjem v zračni atmosferi prihaja do neželene oksidacije. Za primerjavo smo tri vzorce zmleli tudi v inertni atmosferi argona. Produkti, ki smo jih dobili niso vsebovali železovih oksidov, so pa vsebovali nezreagirano železo. Rezultati kažejo, da je za uspešno sintezo FeCu nanodelcev ključna inertna atmosfera. Glede na to, da je pri samem mletju ostalo še tudi nezreagirano železo bo v nadaljevanju potrebno razmišljati v smeri spreminjanja parametrov, ki bodo vodili v uporabo FeCu nanodelcev na področju MH.
Keywords:magnetni nanodelci, FeCu, mehansko mletje, biomedicinske aplikacije, magnetna hipertermija
Place of publishing:Maribor
Place of performance:Maribor
Publisher:[K. Turner]
Year of publishing:2023
Number of pages:1 spletni vir (1 datoteka PDF (VIII, 29 f.))
PID:20.500.12556/DKUM-83899 New window
UDC:620.3:669.15.018.58(043.2)
COBISS.SI-ID:148477955 New window
Publication date in DKUM:30.03.2023
Views:1006
Downloads:151
Metadata:XML DC-XML DC-RDF
Categories:KTFMB - FKKT
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Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:07.03.2023

Secondary language

Language:English
Title:Synthesis of magnetic nanoparticles for applications in biomedicine
Abstract:As part of this thesis, we synthesised magnetic nanoparticles using a high-energy planetary mill. The iron and copper powders were milled in inert and air atmospheres, varying the milling time and sample composition. The aim of the thesis was to investigate whether milling could be used to synthesise a FeCu alloy with a Curie temperature (T_C) within the therapeutic range for applications in magnetic hyperthermia (MH). The synthesis of FeCu nanoparticles began by milling in an air atmosphere. We varied the composition of the sample and extended the milling time. The T_C was measured for all samples by modified thermogravimetric analysis (TGA). The best result was obtained after grinding a sample with composition Fe_40 Cu_60 for 25 hours, but the T_C measurements showed that iron oxides and some unreacted iron were present in the product. A sample of the same composition milled for 20 h was further characterised by X-ray powder diffraction (XRD), which confirmed that undesirable oxidation occurs during milling in an air atmosphere. For comparison, three samples were also ground in an inert argon atmosphere. The products we obtained did not contain iron oxides but did contain unreacted iron. The results show that an inert atmosphere is crucial for the successful synthesis of FeCu nanoparticles. Given that there is also unreacted iron left over from the milling process, further consideration will need to be given to changing the parameters that will lead to the use of FeCu nanoparticles in the MH field.
Keywords:magnetic nanoparticles, FeCu, mechanical milling, biomedical applications, magnetic hyperthermia


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