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Title:Korelacija med hipertenzijo in biološko starostjo in analiza njunega vpliva na smrtnost
Authors:ID Deban, Urša (Author)
ID Štiglic, Gregor (Mentor) More about this mentor... New window
ID Kopitar, Leon (Comentor)
Files:.pdf MAG_Deban_Ursa_2023.pdf (1,32 MB)
MD5: 87771E3A20B1C3EF6FF4694B740C98B0
 
Language:Slovenian
Work type:Master's thesis/paper
Typology:2.09 - Master's Thesis
Organization:FZV - Faculty of Health Sciences
Abstract:Uvod: Povišan krvni tlak oziroma hipertenzija je pomemben dejavnik tveganja srčno-žilnih in ledvičnih obolenj. Biološko starost lahko izračunamo na podlagi klinično merljivih parametrov. Metode: Z namenom analize korelacije med hipertenzijo in biološko starostjo in njuno povezanostjo s smrtnostjo smo analizirali podatke iz podatkovne zbirke NHANES, ki vsebuje podatke o zdravstvenem stanju ameriških prebivalcev. Iz podatkovne zbirke NCHS pa smo pridobili podatke o smrtnosti. Izračunali smo biološko starost in analizirali statistično pomembnost razlik v krvnem tlaku in biološkem staranju med različnimi demografskimi skupinami. Z modelom logistične regresije smo primerjali napovedno moč krvnega tlaka in staranja na smrtnost. Paciente smo razdelili v tri skupine glede na hipertenzivni status ter primerjali statistične parametre med njimi. Rezultati: Zaznali smo nizko korelacijo med krvnim tlakom in kronološko ter biološko starostjo, statistično pomembne razlike v biološkem staranju, ter krvnim tlakom in spolom. Ugotovili smo statistično pomembne razlike med nekaterimi, ne pa vsemi rasami. V analizi skupine hipertenzivnih pacientov nekatere razlike med demografskimi skupinami zbledijo. Izmed vseh testiranih spremenljivk se je kot najmočneje povezana s smrtnostjo pokazala ocena biološke starosti na podlagi krvnih meritev. Razprava in zaključek: Rezultati raziskave izpostavljajo pomen biološke starosti pri nastanku hipertenzije, nakazujejo razlike v krvnem tlaku med demografskimi skupinami in pomen biološke starosti pri oceni tveganja smrtnosti.
Keywords:hipertenzija, krvni tlak, biološko staranje, smrtnost, logistična regresija
Place of publishing:Maribor
Publisher:[U. Deban]
Year of publishing:2023
PID:20.500.12556/DKUM-84018 New window
UDC:616.12-008.331.1:612.67(043.2)
COBISS.SI-ID:152507139 New window
Publication date in DKUM:22.05.2023
Views:708
Downloads:114
Metadata:XML DC-XML DC-RDF
Categories:FZV
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Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:29.03.2023

Secondary language

Language:English
Title:Correlation between hypertension and biological age and analysis of their role in mortality
Abstract:Introduction: Hypertension is a major risk factor for heart and kidney disease, and biological age can be calculated from measurable parameters. Methods: We analysed NHANES data to investigate the relationship between hypertension, biological age, and mortality. We used a logistic regression model to compare the predictive power of blood pressure and aging on mortality. We also compared statistical parameters among different demographic groups and grouped patients based on their hypertensive status. Results: Our findings showed a weak correlation between blood pressure and biological age, significant differences in biological aging, and blood pressure and gender. We found significant differences among some races but not all. The biological age estimate based on blood measurements was the most strongly associated with mortality. Discussion and conclusion: Our study highlights the importance of biological age in the development of hypertension, suggests differences in blood pressure among demographic groups, and emphasizes the role of biological age in assessing mortality risk. Further research is needed to better understand these relationships and to develop interventions that can mitigate the negative health effects of hypertension.
Keywords:hypertension, blood pressure, biological aging, mortality, logistic regression.


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