| Title: | Amoxicillin doped hyaluronic acid/fucoidan multifunctional coatings for medical grade stainless steel orthopedic implants |
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| Authors: | ID Bračič, Matej (Author)
ID Potrč, Sanja (Author)
ID Finšgar, Matjaž (Author)
ID Gradišnik, Lidija (Author)
ID Maver, Uroš (Author)
ID Budasheva, Hanna (Author)
ID Korte, Dorota (Author)
ID Franko, Mladen (Author)
ID Fras Zemljič, Lidija (Author) |
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| Files: |  Amoxicillin_doped_hyaluronic_acid_-Bracic-2023.pdf (10,18 MB)
MD5: 375B2C77A8351DBC9927D591F55B1D5D
 https://www.sciencedirect.com/science/article/pii/S016943322203149X?via%3Dihub
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FS - Faculty of Mechanical Engineering
FKKT - Faculty of Chemistry and Chemical Engineering
MF - Faculty of Medicine
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| Abstract: | This work investigated the potential of amoxicillin-doped hyaluronic acid/fucoidan multifunctional coatings on medical grade stainless steel as biocompatible, osteointegration enhancing, antimicrobial, and bacterial biofilm inhibiting coatings for orthopedic implants. The coatings were prepared by layer-by-layer spin coating and confirmed by optical contact angle goniometry and infrared spectroscopy. Time-of-flight secondary ion mass spectrometry showed a homogeneous distribution of the individual layers. In contrast, thermal diffusivity, and thermal conductivity measurements by photothermal beam deflection spectrometry showed diffusion of the amoxicillin into the hyaluronic acid and fucoidan layers. In vitro release of amoxicillin showed complete release within one hour, as reflected by the formation of inhibition zones against Staphylococcus aureus and Escherichia coli. Synergistic effects were observed between the hyaluronic acid and amoxicillin in inhibiting S.Aureus biofilm, and between the fucoidan and amoxicillin in improving the antioxidant properties by an ABTS radical scavenging assay. Biocompatibility was determined with human osteoblasts, confirming the potential of such multifunc- tional coatings to enhance the bioactivity of steel-based orthop edic implants. |
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| Keywords: | orthopedic implant, medical grade stainless steel, amoxicillin, hyaluronic acid, fucoidan, multifunctional coating |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 19.07.2022 |
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| Article acceptance date: | 04.11.2022 |
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| Publication date: | 09.11.2022 |
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| Publisher: | Elsevier |
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| Year of publishing: | 2023 |
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| Number of pages: | str. 1-11 |
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| Numbering: | Letn. 611, part A |
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| PID: | 20.500.12556/DKUM-85106  |
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| UDC: | 54 |
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| ISSN on article: | 0169-4332 |
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| COBISS.SI-ID: | 130119171 |
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| DOI: | 10.1016/j.apsusc.2022.155621 |
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| Publication date in DKUM: | 18.08.2023 |
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| Views: | 749 |
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| Downloads: | 184 |
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| Metadata: |    |
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| Categories: | Misc.
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