| Naslov: | Peripheral blood transcriptome in breast cancer patients as a source of less invasive immune biomarkers for personalized medicine, and implications for triple negative breast cancer |
|---|
| Avtorji: | ID Čelešnik, Helena Sabina (Avtor)
ID Potočnik, Uroš (Avtor) |
|---|
| Datoteke: |  Peripheral_Blood_Transcriptome_i-Celesnik-2022.pdf (1,74 MB)
MD5: 616993E41B421AF14BADEB86410B6F00
 https://www.mdpi.com/2072-6694/14/3/591
https://doi.org/10.3390/cancers14030591
|
|---|
| Jezik: | Angleški jezik |
|---|
| Vrsta gradiva: | Znanstveno delo |
|---|
| Tipologija: | 1.02 - Pregledni znanstveni članek |
|---|
| Organizacija: | FKKT - Fakulteta za kemijo in kemijsko tehnologijo
MF - Medicinska fakulteta
|
|---|
| Opis: | Transcriptome studies of peripheral blood cells can advance our understanding of the systemic immune response to the presence of cancer and the mechanisms underlying cancer onset and progression. This enables the identification of novel minimally invasive immune biomarkers for early cancer detection and personalized cancer management and may bring forward new immunotherapy options. Recent blood gene expression analyses in breast cancer (BC) identified distinct patient subtypes that differed in the immune reaction to cancer and were distinct from the clinical BC subtypes, which are categorized based on expression of specific receptors on tumor cells. Introducing new BC subtypes based on peripheral blood gene expression profiles may be appropriate, since it may assist in BC prognosis, the identification of patients likely to benefit from immunotherapy, and treatment efficacy monitoring. Triple-negative breast cancer (TNBC) is an aggressive, heterogeneous, and difficult-to-treat disease, and identification of novel biomarkers for this BC is crucial for clinical decision-making. A few studies have reported TNBC-enriched blood transcriptional signatures, mostly related to strong inflammation and augmentation of altered immune signaling, that can differentiate TNBC from other classical BC subtypes and facilitate diagnosis. Future research is geared toward transitioning from expression signatures in unfractionated blood cells to those in immune cell subpopulations. |
|---|
| Ključne besede: | triple negative breast cancer, transcriptome, peripheral blood, PBMC, gene expression, immune biomarker |
|---|
| Status publikacije: | Objavljeno |
|---|
| Verzija publikacije: | Objavljena publikacija |
|---|
| Datum objave: | 01.01.2022 |
|---|
| Leto izida: | 2022 |
|---|
| Št. strani: | str. 1-21 |
|---|
| Številčenje: | Letn. 14, Št. 3 |
|---|
| PID: | 20.500.12556/DKUM-85256  |
|---|
| UDK: | 618.19-006 |
|---|
| COBISS.SI-ID: | 94899715 |
|---|
| DOI: | 10.3390/cancers14030591 |
|---|
| ISSN pri članku: | 2072-6694 |
|---|
| Datum objave v DKUM: | 23.08.2023 |
|---|
| Število ogledov: | 568 |
|---|
| Število prenosov: | 71 |
|---|
| Metapodatki: |    |
|---|
| Področja: | Ostalo
|
|---|
|
:
|
Kopiraj citat |
|---|
| | | | Skupna ocena: | (0 glasov) |
|---|
| Vaša ocena: | Ocenjevanje je dovoljeno samo prijavljenim uporabnikom. |
|---|
| Objavi na: |  |
|---|
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše
podrobnosti ali sproži prenos. |
