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Title:Primerjava podpornih vektorjev, naključnih gozdov in nevronskih mrež za napoved odziva na zdravljenje z adalimumabom pri slovenskih bolnikih s crohnovo boleznijo
Authors:ID Nemec, Katja (Author)
ID Gorenjak, Mario (Mentor) More about this mentor... New window
ID Potočnik, Uroš (Comentor)
Files:.pdf MAG_Nemec_Katja_2024.pdf (3,95 MB)
MD5: 221EC61A817C497CC370467D511A567C
 
Language:Slovenian
Work type:Master's thesis
Typology:2.09 - Master's Thesis
Organization:FZV - Faculty of Health Sciences
Abstract:Uvod: V našem magistrskem delu smo želeli ugotoviti učinkovitost metod strojnega učenja pri napovedi odziva bolnikov s Chronovo boleznijo na biološko zdravilo adalimumab. Metode: Raziskava je vključevala 88 vzorcev, ki so bili analizirani glede na genetske, klinične in mešane podatke v različnih tednih zdravljenja. Uporabljene metode, kot so naključni gozdovi (RF), podporni vektorji (SVM) in nevronske mreže (NNET), so bile evalvirane z uporabo različnih metrik natančnosti, občutljivosti in Youdenovega indeksa. Rezultati: Rezultati kažejo, da je metoda RF najboljša na mešanih podatkih, SVM izstopa pri kliničnih, medtem ko NNET in RF dosegata najboljše rezultate na genetskih podatkih v različnih obdobjih zdravljenja. Uporaba metode "bagging" je izboljšala natančnost, še posebej pri RF. Kljub temu se zahteva previdnost pri interpretaciji zaradi omejene velikosti vzorca. Razprava: Naša analiza poudarja potrebo po preudarnem izboru metode, odvisnem od specifičnih značilnosti podatkov in ciljev analize. Sklep: Naše ugotovitve na podlagi analize predstavljajo osnovo za nadaljnje raziskave v smeri izboljšanja natančnosti modelov napovedi zdravljenja.
Keywords:Crohnova bolezen, bioinformatika, napovedni modeli, strojno učenje
Place of publishing:Maribor
Publisher:[K. Nemec]
Year of publishing:2024
PID:20.500.12556/DKUM-86930 New window
UDC:004.43:615.32:616.34-002(043.2)
COBISS.SI-ID:190297859 New window
Publication date in DKUM:26.03.2024
Views:410
Downloads:47
Metadata:XML DC-XML DC-RDF
Categories:FZV
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Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:29.01.2024

Secondary language

Language:English
Title:Comparison of support vectors, random forests and neural networks for predicting the response to adalimumab treatment in slovenian patients with crohn´s disease
Abstract:Introduction: In our master's thesis, we aimed to assess the effectiveness of machine learning methods in predicting the response of patients with Crohn's disease to the biological drug adalimumab. Methods: The study involved 88 samples, analyzed based on genetic, clinical, and combined data over various treatment weeks. Employed methods, such as Random Forest (RF), Support Vector Machine (SVM), and Neural Network (NNET), were evaluated using diverse accuracy metrics, sensitivity, and the Youden Index. Results: Findings indicate RF as optimal for mixed data, SVM excelling in clinical data, while NNET and RF performed best on genetic data across different treatment periods. The use of "bagging" improved accuracy, particularly with RF. However, caution is warranted in interpretation due to the limited sample size. Discussion: Our analysis underscores the need for a judicious method selection, contingent on specific data characteristics and analysis goals. Conclusion: Our insights, derived from this analysis, serve as a foundation for further research aimed at enhancing the accuracy of treatment prediction models.
Keywords:Crohn’s disease, bioinformatics, prediction models, machine learning


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