| Title: | Hybrid polylactic-acid–pectin aerogels : synthesis, structural properties, and drug release |
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| Authors: | ID Horvat, Gabrijela (Author)
ID Žvab, Klara (Author)
ID Knez, Željko (Author)
ID Novak, Zoran (Author) |
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| Files: |  Horvat-2023-Hybrid_Polylactic-Acid-Pectin_Aero.pdf (2,62 MB)
MD5: 5BB389A1675DFD1DF1544DE28B3F7232
 https://www.mdpi.com/2073-4360/15/2/407
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FKKT - Faculty of Chemistry and Chemical Engineering
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| Abstract: | Wound-dressing materials often include other materials stimulating wound healing. This research describes the first formulation of biodegradable hybrid aerogels composed of polylactic acid and pectin. The prepared hybrid material showed a highly porous structure with a surface area of 166 +/- 22.6 m(2)center dot g(-1). The addition of polylactic acid may have decreased the surface area of the pure pectin aerogel, but it improved the stability of the material in simulated body fluid (SBF). The pure pectin aerogel showed a high swelling and degradation ratio after 3 h. The addition of the polylactic acid prolonged its stability in the simulated body fluid from 24 h to more than one week, depending on the amount of polylactic acid. Biodegradable aerogels were loaded with indomethacin and diclofenac sodium as model drugs. The entrapment efficiencies were 63.4% and 62.6% for indomethacin and diclofenac sodium, respectively. Dissolution of both drugs was prolonged up to 2 days. Finally, sodium percarbonate and calcium peroxide were incorporated into the bioaerogels as chemical oxygen sources, to evaluate oxygen generation for potential wound healing applications. |
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| Keywords: | hybrid aerogels, bioaerogel, pectin, polylactic acid, wound healing |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 23.12.2022 |
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| Article acceptance date: | 10.01.2023 |
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| Publication date: | 12.01.2023 |
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| Publisher: | MDPI |
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| Year of publishing: | 2023 |
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| Number of pages: | Str. 1-12 |
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| Numbering: | Letn. 15, Št. 2 |
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| PID: | 20.500.12556/DKUM-87121  |
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| UDC: | 66.02 |
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| ISSN on article: | 2073-4360 |
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| COBISS.SI-ID: | 137625603 |
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| DOI: | 10.3390/polym15020407 |
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| Publication date in DKUM: | 20.02.2024 |
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| Views: | 561 |
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| Downloads: | 53 |
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| Metadata: |    |
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| Categories: | Misc.
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