| Title: | UCHL1, besides leptin and fibronectin, also could be a sensitive marker of the relapsing–remitting type of multiple sclerosis |
|---|
| Authors: | ID Görska, Ewelina (Author)
ID Tylicka, Marzena (Author)
ID Hermanowicz, Adam (Author)
ID Matuszczak, Ewa (Author)
ID Sankiewicz, Anna (Author)
ID Gorodkiewicz, Ewa (Author)
ID Hermanowicz, Justyna (Author)
ID Karpińska, Elźbieta (Author)
ID Socha, Katarzyna (Author)
ID Kochanowicz, Jan (Author)
ID Homšak, Evgenija (Author) |
|---|
| Files: |  Górska-2023-UCHL1,_besides_leptin_and_fibronec.pdf (1,24 MB)
MD5: 64688FD3399558A6896539A5DEB73039
 https://doi.org/10.1038/s41598-023-30237-3
|
|---|
| Language: | English |
|---|
| Work type: | Scientific work |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: | MF - Faculty of Medicine
|
|---|
| Abstract: | Research on the markers of immunoregulatory response in multiple sclerosis (MS) is still of great importance. The aim of our study was the evaluation of leptin, fibronectin, and UCHL1 concentrations as potential biomarkers of a relapsing-remitting type of MS (RRMS). Surface Plasmon Resonance Imaging (SPRI) biosensors were used for the evaluation of proteins concentrations in 100 RRMS patients and 46 healthy volunteers. Plasma leptin, fibronectin, and UCHL1 concentrations were significantly higher in RRMS patients compared to the control group (p < 0.001, respectively). UCHL1 concentration evaluation revealed the highest diagnostic sensitivity (100%) and negative predictive value (100%) in differentiating MS patients from healthy individuals. There was no significant difference in the UCHL1 concentrations depending on the patient's sex, the presence of relapse within the last 24 months, and the EDSS value (p > 0.05, respectively). In RRMS patients UCHL1 concentration positively correlated with fibronectin levels (r = 0.3928; p < 0.001). In the current cohort of patients plasma UCHL1 concentration was independent of the time of MS relapse and the severity of neurological symptoms. Thus current study may indicate that plasma UCHL1, besides leptin and fibronectin, also could be a promising high-sensitive potential biomarker of relapsing-remitting type of MS. However, these results should be validated with a larger group of patients, taking into account neuroimaging and cerebrospinal fluid analysis data, and by comparing them to patients with other neurological diseases as a control group. |
|---|
| Keywords: | immunoregulatory response, multiple sclerosis, biomarkers, leptin, fibronectins, ubiquitin thiolesterase |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Submitted for review: | 08.11.2022 |
|---|
| Article acceptance date: | 20.02.2023 |
|---|
| Publication date: | 28.02.2023 |
|---|
| Publisher: | Nature Publishing Group |
|---|
| Year of publishing: | 2023 |
|---|
| Number of pages: | Str. 1-10 |
|---|
| Numbering: | Letn. 13, Št. članka 3423 |
|---|
| PID: | 20.500.12556/DKUM-87128  |
|---|
| UDC: | 616.8 |
|---|
| ISSN on article: | 2045-2322 |
|---|
| COBISS.SI-ID: | 143814659 |
|---|
| DOI: | 10.1038/s41598-023-30237-3 |
|---|
| Publication date in DKUM: | 21.02.2024 |
|---|
| Views: | 404 |
|---|
| Downloads: | 25 |
|---|
| Metadata: |    |
|---|
| Categories: | Misc.
|
|---|
|
:
|
Copy citation |
|---|
| | | | Average score: | (0 votes) |
|---|
| Your score: | Voting is allowed only for logged in users. |
|---|
| Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
