| Title: | Treatment of vulvar cancer recurrences with electrochemotherapy : a detailed analysis of possible causes for unsuccessful treatment |
|---|
| Authors: | ID Vivod, Gregor (Author)
ID Jesenko, Tanja (Author)
ID Gašljević, Gorana (Author)
ID Kovačević, Nina (Author)
ID Omerzel, Maša (Author)
ID Serša, Gregor (Author)
ID Merlo, Sebastjan (Author)
ID Čemažar, Maja (Author) |
|---|
| Files: |  Vivod-2023-Treatment_of_vulvar_cancer_recurren.pdf (1,45 MB)
MD5: 1850E9D1FF767B28EE2AF570FA4D9557
 https://doi.org/10.2478/raon-2023-0010
|
|---|
| Language: | English |
|---|
| Work type: | Scientific work |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: | MF - Faculty of Medicine
|
|---|
| Abstract: | Background. Electrochemotherapy has good local effectiveness in the treatment of vulvar cancer. Most studies have reported the safety and effectiveness of electrochemotherapy for palliative treatment of gynecological cancers and mostly vulvar squamous cell carcinoma. Some tumors, however, fail to respond to electrochemotherapy. The biological features/determinants for the nonresponsiveness are not determined yet. Patient and methods. A recurrence of vulvar squamous cell carcinoma was treated by electrochemotherapy using intravenous administration of bleomycin. The treatment was performed by hexagonal electrodes according to standard operating procedures. We analyzed the factors that could determine nonresponsiveness to electrochemotherapy. Results. Based on the presented case of nonresponsive vulvar recurrence to electrochemotherapy, we hypothesize that the vasculature of the tumors prior to treatment may predict the response to electrochemotherapy. The histological analysis showed minimal presence of blood vessels in the tumor. Thus, low perfusion may reduce drug delivery and lead to a lower response rate because of the minor antitumor effectiveness of vascular disruption. In this case, no immune response in the tumor was elicited by electrochemotherapy. Conclusions. In this case, of nonresponsive vulvar recurrence treated by electrochemotherapy, we analyzed possible factors that could predict treatment failure. Based on histological analysis, low vascularization of the tumor was observed, which hampered drug delivery and distribution and resulted in no vascular disrupting action of electrochemotherapy. All these factors could contribute to ineffective treatment with electrochemotherapy. |
|---|
| Keywords: | electrochemotherapy, bleomycin, vulvar cancer |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Submitted for review: | 21.12.2022 |
|---|
| Article acceptance date: | 11.01.2023 |
|---|
| Publication date: | 17.02.2023 |
|---|
| Publisher: | Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology |
|---|
| Year of publishing: | 2023 |
|---|
| Number of pages: | Str. 121-126 |
|---|
| Numbering: | Letn. 57, Št. 1 |
|---|
| PID: | 20.500.12556/DKUM-88343  |
|---|
| UDC: | 618.16:616-006 |
|---|
| ISSN on article: | 1318-2099 |
|---|
| COBISS.SI-ID: | 141773827 |
|---|
| DOI: | 10.2478/raon-2023-0010 |
|---|
| Publication date in DKUM: | 17.04.2024 |
|---|
| Views: | 294 |
|---|
| Downloads: | 33 |
|---|
| Metadata: |    |
|---|
| Categories: | Misc.
|
|---|
|
:
|
Copy citation |
|---|
| | | | Average score: | (0 votes) |
|---|
| Your score: | Voting is allowed only for logged in users. |
|---|
| Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
