| Title: | Antibacterial effect of topically administered tranexamic acid in large joint arthroplasty |
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| Authors: | ID Slokar, Urban (Author)
ID Kovač, Simon (Author)
ID Cör, Andrej (Author)
ID Šuster, Katja (Author) |
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| Files: |  Slokar-2023-Antibacterial_Effect_of_Topically.pdf (1,96 MB)
MD5: 4FB3BCA1CA8E39602D3B93459640E7FA
 https://doi.org/10.3390/app13169050
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | MF - Faculty of Medicine
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| Abstract: | Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine and is commonly used as an antifibrinolytic agent in large joint surgery, such as knee arthroplasty, to minimize blood loss and its associated complications. Some studies have suggested that perioperative intravenous TXA application lowers the incidence of postoperative infections after hip and knee arthroplasty. While its effects on bacteria are not its primary purpose, more research is needed further to elucidate the extent of TXA’s impact on bacterial inhibition and its clinical relevance. In order to determine possible inhibitory effects, 22 clinically relevant bacterial strains were exposed to different TXA concentrations. Two different assays were performed: a microdilution assay with traditional endpoint measurements and a kinetic growth assay for a time-dependent susceptibility assessment. With the microdilution technique, a growth inhibitory effect became evident at higher TXA concentrations (50 and 100 mg/mL) on eight tested bacterial strains, of which four demonstrated absence of growth at 100 mg/mL, suggesting minimal inhibitory concentration. However, the kinetic growth assay revealed more specific TXA-induced dynamic changes in the bacterial growth of all tested bacterial strains. This study showed that TXA affects the growth dynamics of bacteria by altering their lag phase duration, exponential growth rate, and population density and may contribute to the prevention of implant-associated infections. |
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| Keywords: | tranexamic acid, bacterial growth, antimicrobial effect, topical administration, arthroplasty |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 24.05.2023 |
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| Article acceptance date: | 05.08.2023 |
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| Publication date: | 08.08.2023 |
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| Publisher: | MDPI |
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| Year of publishing: | 2023 |
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| Number of pages: | Str. 1-12 |
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| Numbering: | Letn. 13, Št. 16, št. članka 9050 |
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| PID: | 20.500.12556/DKUM-88374  |
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| UDC: | 617.3 |
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| ISSN on article: | 2076-3417 |
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| COBISS.SI-ID: | 160945923 |
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| DOI: | 10.3390/app13169050 |
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| Publication date in DKUM: | 19.04.2024 |
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| Views: | 325 |
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| Downloads: | 24 |
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| Metadata: |    |
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| Categories: | Misc.
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