| Title: | Broad host range may be a key to long-term persistence of bacteriophages infecting intestinal Bacteroidaceae species |
|---|
| Authors: | ID Hedžet, Stina (Author)
ID Rupnik, Maja (Author)
ID Accetto, Tomaž (Author) |
|---|
| Files: |  Hedzet-2022-Broad_host_range_may_be_a_key_to_l.pdf (1,53 MB)
MD5: 375A11E353EC9D88090CFA6EF3DC7863
 https://doi.org/10.1038/s41598-022-25636-x
|
|---|
| Language: | English |
|---|
| Work type: | Scientific work |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: | MF - Faculty of Medicine
|
|---|
| Abstract: | The longitudinal studies have found that the human gut microbiota is stable over time with some major bacterial lineages or even strains persisting for years. This was recently extended to gut bacteriophages using the metagenomic data. Here, we focused on cultivation of the major Bacteroidetes of human gut, the Bacteroides and Phocaeicola strains, and their bacteriophages from two healthy donors. The persistence of Bacteroides and Phocaeicola species and strains was confirmed. We isolated 28 genetically different phages grouped into seven distinct clusters, two of these were new. Moreover, the bacteriophages from several groups, although being genetically quite homogeneous, had the ability to infect the strains belonging to different species isolated from several sampling time-points and different donors. We propose that the ability to infect several host species, which differ in their nutritional niches, may promote long-term persistence of dominant gut bacteriophage groups. |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Submitted for review: | 19.07.2022 |
|---|
| Article acceptance date: | 02.12.2022 |
|---|
| Publication date: | 06.12.2022 |
|---|
| Publisher: | Nature Publishing Group |
|---|
| Year of publishing: | 2022 |
|---|
| Number of pages: | Str. 1-11 |
|---|
| Numbering: | Letn. 12, Št. članka 21098 |
|---|
| PID: | 20.500.12556/DKUM-89125  |
|---|
| UDC: | 579.61:578.347:579.844.1 |
|---|
| ISSN on article: | 2045-2322 |
|---|
| COBISS.SI-ID: | 133368323 |
|---|
| DOI: | 10.1038/s41598-022-25636-x |
|---|
| Publication date in DKUM: | 17.06.2024 |
|---|
| Views: | 252 |
|---|
| Downloads: | 16 |
|---|
| Metadata: |    |
|---|
| Categories: | Misc.
|
|---|
|
:
|
Copy citation |
|---|
| | | | Average score: | (0 votes) |
|---|
| Your score: | Voting is allowed only for logged in users. |
|---|
| Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
