| Naslov: | The role of methylation of host and/or human papillomavirus (HPV) DNA in management of cervical intraepithelial neoplasia grade 2 (CIN2) lesions |
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| Avtorji: | ID Dovnik, Andraž (Avtor)
ID Poljak, Mario (Avtor) |
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| Datoteke: |  Dovnik-2023-The_Role_of_Methylation_of_Host_an.pdf (340,44 KB)
MD5: D777FB9E07172E6F5C5BF12E8A615B75
 https://doi.org/10.3390/ijms24076479
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Znanstveno delo |
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| Tipologija: | 1.02 - Pregledni znanstveni članek |
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| Organizacija: | MF - Medicinska fakulteta
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| Opis: | Cervical intraepithelial neoplasia grade 2 (CIN2) is an intermediate stage between CIN 1, which is a low-grade lesion, and CIN3, which is the immediate precursor of cervical cancer (CC). Traditionally, CIN2 was regarded as a high-grade lesion and was treated with conization or ablative methods. In recent years, there has been a shift in the management of younger patients, who are now more often being managed conservatively due to frequent spontaneous CIN2 regression and possible adverse effects of treatment on future pregnancies. Because the risk of progression to CC still exists with conservative management, a personalized approach is needed to identify patients with a higher probability of progression. In this regard, research has focused on the role of host and human papillomavirus (HPV) gene methylation. This systematic review summarizes the current knowledge regarding conservative CIN2 management focusing on the main methylation markers and its implementation in conservative CIN2 management, and it describes major ongoing longitudinal studies on the subject. The review showed that DNA methylation is an accurate predictor of disease progression and a valid triage tool for HPV-positive women, with CIN2 performing better than triage cytology. Because virtually all CCs are methylation-positive, methylation-negative women at baseline have an extremely low risk of CC. |
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| Ključne besede: | cervical intraepithelial lesion, human papillomavirus, gene methylation |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 07.03.2023 |
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| Datum sprejetja članka: | 28.03.2023 |
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| Datum objave: | 30.03.2023 |
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| Založnik: | MDPI |
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| Leto izida: | 2023 |
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| Št. strani: | Str. 1-15 |
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| Številčenje: | Letn. 24, Št. 7, št. članka 6479 |
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| PID: | 20.500.12556/DKUM-89543  |
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| UDK: | 618.1 |
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| COBISS.SI-ID: | 147516675 |
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| DOI: | 10.3390/ ijms24076479 |
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| ISSN pri članku: | 1422-0067 |
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| Datum objave v DKUM: | 19.07.2024 |
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| Število ogledov: | 460 |
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| Število prenosov: | 21 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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