| Title: | Synthesis, purification, and cell-toxicity of a choline betainate |
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| Authors: | ID Jurko, Lucija (Author)
ID Hostnik, Gregor (Author)
ID Steindorfer, Tobias Alexander (Author)
ID Štraser, Alja (Author)
ID Bošković, Perica (Author)
ID Bračič, Matej (Author)
ID Žegura, Bojana (Author)
ID Kargl, Rupert (Author) |
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| Files: |  1-s2.0-S0022286024011001-main.pdf (3,60 MB)
MD5: BEE656A1B760959D4C34C99872E71D35
 https://www.sciencedirect.com/science/article/pii/S0022286024011001?via%3Dihub#sec0020
http://dx.doi.org/10.1016/j.molstruc.2024.138581
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FS - Faculty of Mechanical Engineering
FKKT - Faculty of Chemistry and Chemical Engineering
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| Abstract: | In this work, choline chloride and betaine hydrochloride were condensed into a - to our knowledge - unreported choline betainate (N,N,N-trimethyl-2-oxo-2-(2-(trimethylammonio)ethoxy)ethanaminium chloride) using 1,1′-carbonyldiimidazole (CDI) activation of betaine hydrochloride in dimethylsulfoxide. The product and reaction intermediates were isolated, purified by preparative HPLC and analyzed in detail by infrared and nuclear magnetic resonance spectroscopy. The final product has a high cytotoxicity for L929 mouse fibroblasts, and low antibacterial activity against P. Aeruginosa and S. Aureus at concentrations of up to 20 mg/ml. It could potentially further be investigated for similar uses as suxamethonium chloride, a muscle relaxant drug. |
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| Keywords: | molekularna biologija, holin klorid, betain hidroklorid, karbonildiimidazol, protimikrobnost, cititoksičnost, choline chloride, betaine hydrochloride, carbonyldiimidazole, HPLC, antimicrobial, cytotoxicity |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 22.01.2024 |
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| Article acceptance date: | 07.05.2024 |
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| Publication date: | 08.05.2024 |
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| Publisher: | Elsevier |
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| Year of publishing: | 2024 |
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| Number of pages: | [16] str. |
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| Numbering: | [article no.] 138581 |
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| PID: | 20.500.12556/DKUM-89746  |
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| UDC: | 577:576 |
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| ISSN on article: | 1872-8014 |
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| COBISS.SI-ID: | 195589379 |
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| DOI: | 10.1016/j.molstruc.2024.138581 |
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| Copyright: | © 2024 The Author(s) |
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| Publication date in DKUM: | 28.01.2026 |
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| Views: | 152 |
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| Downloads: | 2 |
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| Metadata: |    |
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| Categories: | Misc.
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