| Title: | Antibacterial Komagataeibacter hansenii nanocellulose membranes with avocado seed bioactive compounds |
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| Authors: | ID Kupnik, Kaja (Author)
ID Primožič, Mateja (Author)
ID Kokol, Vanja (Author)
ID Knez, Željko (Author)
ID Leitgeb, Maja (Author) |
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| Files: |  s10570-024-05839-3.pdf (1,80 MB)
MD5: 2C160F32057E63529F342A8B364B72D3
 https://link.springer.com/article/10.1007/s10570-024-05839-3
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FKKT - Faculty of Chemistry and Chemical Engineering
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| Abstract: | Biocompatible, mechanically stable, highly hydrophilic/swellable and safe antibacterial biomaterials are crucial for wound dressing and other applications in the health sector. Therefore, this study was conducted for the development of bacterial nanocellulose membranes, which were, for the frst time, enriched with bacteriostatic and bactericidal efective avocado seed extracts prepared by diferent extraction techniques (ultrasonic, Soxhlet, high pressure with supercritical carbon dioxide). First, the production process of bacterial nanocellulose membranes from Komagataeibacter hansenii bacteria was optimized related to the fermentation media composition and
culture conditions, resulting in bacterial nanocellulose membranes with up to 83% crystallinity and 54.5 g/L
yield. The morphological structure of the membranes was varied further by using air- and freeze-drying
processes. The Soxhlet and high pressure with supercritical carbon dioxide avocado seed extracts with the
most charge negative surface (-33 mV) and smallest hydrodynamic size (0.1 µm) thus resulted in 100%
reduction of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus with up to log
reduction of 2.56 and up to 100% bactericidal efficacy after 24 h of exposure, and at 14 mg/g of avocado
seed extracts integrated in the bacterial nanocellulose membranes homogeneously. The high swelling (up
to 600%) and water retention ability of avocado seed extracts enriched bacterial nanocellulose membranes,
with a biocidal release up to 2.71 mg/mL, shows potential for antibacterial applications in the biomedicine, cosmetics, and pharmaceutical industries. |
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| Keywords: | bacterial nanocellulose membrane, avocado seed extracts, extraction, swelling, release, antibacterial activity |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 24.10.2023 |
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| Article acceptance date: | 02.03.2024 |
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| Publication date: | 02.04.2024 |
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| Publisher: | Springer Link (Kluwer) |
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| Year of publishing: | 2024 |
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| Number of pages: | 23 str. |
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| Numbering: | let. 31 |
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| PID: | 20.500.12556/DKUM-90151  |
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| UDC: | 620.3 |
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| ISSN on article: | 1572-882X |
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| COBISS.SI-ID: | 191181059 |
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| DOI: | 10.1007/s10570-024-05839-3 |
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| Copyright: | © The Author(s) 2024 |
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| Publication date in DKUM: | 23.08.2024 |
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| Views: | 310 |
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| Downloads: | 23 |
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| Metadata: |    |
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| Categories: | Misc.
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