| Title: | Reinforcing ethyl cellulose aerogels with poly(lactic acid) for enhanced bone regeneration |
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| Authors: | ID Horvat, Gabrijela (Author)
ID Rožanc, Jan (Author)
ID Maver, Uroš (Author)
ID Finšgar, Matjaž (Author)
ID Knez, Željko (Author)
ID Novak, Zoran (Author) |
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| Files: |  s10570-024-05905-w.pdf (2,87 MB)
MD5: 9B10AB0B9E8CFAEA516EA948134F453A
 https://link.springer.com/article/10.1007/s10570-024-05905-w
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FKKT - Faculty of Chemistry and Chemical Engineering
MF - Faculty of Medicine
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| Abstract: | Developing double porous biodegradable and biocompatible scafolds that can incorporate and release drugs in a controlled manner holds immense potential in regenerative medicine. This study presents a synthesis method for preparing a macro-mesoporous scafold, where poly(lactic acid) adds to the macroporous region and mechanical properties, and ethyl cellulose adds to the surface area (182 m2 /g). High surface area enables the incorporation of model drug indomethacin with an entrapment efciency of 17.0% and its later controlled release profle. The resulting scafold has desirable mechanical properties in the range of a natural trabecular bone with a compressive modulus of 22.4 MPa. The material is stable in the simulated body fuids for 120 days before the slow degradation starts. In vitro studies demonstrate the material’s ability to support bone cell adhesion, proliferation, and diferentiation, promoting osteogenic activity. Overall, the unique combination of poly(lactic acid) and ethyl cellulose produces advanced materials with tailored macro and mesopore properties, remarkable mechanical properties, optimal degradation rate, and drug delivery potential, making it a promising candidate for bone scafolds in regenerative medicine and tissue engineering |
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| Keywords: | bio composite, polymer-matrix composites (PMCs), polymers, porosity/voids, secondary ion mass spectrometry |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 16.10.2023 |
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| Article acceptance date: | 08.04.2024 |
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| Publication date: | 13.04.2024 |
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| Publisher: | Kluwer (Springer Link) |
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| Year of publishing: | 2024 |
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| Number of pages: | 19 str. |
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| PID: | 20.500.12556/DKUM-90159  |
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| UDC: | 66.02 |
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| ISSN on article: | 1572-882X |
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| COBISS.SI-ID: | 192685315 |
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| DOI: | 10.1007/s10570-024-05905-w |
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| Copyright: | © The Author(s) 2024 |
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| Publication date in DKUM: | 23.08.2024 |
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| Views: | 416 |
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| Downloads: | 24 |
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| Metadata: |    |
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| Categories: | Misc.
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