| Naslov: | Antithrombogenic polysaccharide coatings to improve hemocompatibility, protein-repellence, and endothelial cell response |
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| Avtorji: | ID Bračič, Matej (Avtor)
ID Nagy, Bence M. (Avtor)
ID Plohl, Olivija (Avtor)
ID Lackner, Florian (Avtor)
ID Steindorfer, Tobias Alexander (Avtor)
ID Fischer, Roland (Avtor)
ID Heinze, Thomas (Avtor)
ID Olschewski, Andrea (Avtor)
ID Stana-Kleinschek, Karin (Avtor)
ID Nagaraj, Chandran (Avtor)
ID Mohan, Tamilselvan (Avtor) |
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| Datoteke: |  1-s2.0-S2589004224019175-main.pdf (5,07 MB)
MD5: 202050ACAC933F80647C78442593E186
 https://www.sciencedirect.com/science/article/pii/S2589004224019175?via%3Dihub
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Članek v reviji |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | FS - Fakulteta za strojništvo
FERI - Fakulteta za elektrotehniko, računalništvo in informatiko
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| Opis: | Polyester biomaterials play a crucial in vascular surgery, but suffer from unspecific protein adsorption,
thrombogenicity, and inadequate endothelial cell response, which limit their success. To address these issues, we investigated the functionalization of polyester biomaterials with antithrombogenic polysaccharide coatings. A two-step and water-based method was used to coat cationized polycaprolactone with
different sulfated polysaccharides (SPS), which resulted in long-term stability, tunable morphology,
roughness, film thickness, chemical compositions, zeta potential, and water content. The coatings significantly increased the anticoagulant activity and reduced the thrombogenicity of polycaprolactone, particularly with highly sulfated heparin and cellulose sulfate. Less SPS, such as chondroitin sulfate, fucoidan,
and carrageenan, despite showing reduced anticoagulant activity, also exhibited lower fibrinogen adsorption. The adhesion and viability of human primary endothelial cells cultured on modified polycaprolactone
correlated with the type and sulfate content of the coatings. |
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| Ključne besede: | polyester biomaterials, vascular surgery, antithrombogenic polysaccharide coatings |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 25.03.2024 |
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| Datum sprejetja članka: | 05.08.2024 |
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| Datum objave: | 02.09.2024 |
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| Založnik: | Elsevier |
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| Leto izida: | 2024 |
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| Št. strani: | 20 str. |
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| Številčenje: | Vol. 27, iss. 9, [article no.] 110692 |
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| PID: | 20.500.12556/DKUM-90600  |
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| UDK: | 577.114.4:60 |
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| COBISS.SI-ID: | 206885891 |
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| DOI: | 10.1016/j.isci.2024.110692 |
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| ISSN pri članku: | 2589-0042 |
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| Avtorske pravice: | © 2024 The Author(s). Published by Elsevier Inc. |
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| Datum objave v DKUM: | 10.09.2024 |
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| Število ogledov: | 202 |
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| Število prenosov: | 46 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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