| Naslov: | Translational regulation in hepatocellular carcinogenesis |
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| Avtorji: | ID Bračič Tomažič, Suzana (Avtor)
ID Schatz, Christoph (Avtor)
ID Haybaeck, Johannes (Avtor) |
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| Datoteke: |  Tomazic-2021-Translational_Regulation_in_Hepat.pdf (4,21 MB)
MD5: E55BEBA045618C20F661AE541769F393
 https://doi.org/10.2147/DDDT.S255582
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Znanstveno delo |
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| Tipologija: | 1.02 - Pregledni znanstveni članek |
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| Organizacija: | MF - Medicinska fakulteta
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| Opis: | The mortality of hepatocellular carcinoma (HCC) is distributed unevenly worldwide. One of the major causes is hepatitis B or hepatitis C virus infection and the development and progression of liver cirrhosis. The carcinogenesis of HCC is among others regulated via the mTOR (mechanistic target of rapamycin) signaling pathway and represents a possible method of targeted treatment. The aim of our article was to address the most recent clinical advances and findings of basic studies on the mTOR signaling pathway and the involved factors. Risk factors play a key role in dysregulation of the signaling pathway, where both mTORCs are upregulated and protein synthesis is altered. eIFs and, to a lesser extent, eEFs play an essential role in this process. Whether the factor will be upregulated or downregulated, among others, depends on hepatitis B/C virus infection. The amount of a particular factor in a patient sample lets us know whether HCC recurrence will occur, what is the likelihood of chemoresistance, and what outcome is predicted for patients with an increased value. Our analysis shows that in addition to mTOR, eIF3, eIF4, and eIF5 play an important role, as they can serve as biomarkers for non- and virus-related HCC. |
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| Ključne besede: | mTOR, virus related HCC, non-virus related HCC, cancer, translation initiation, liver |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 03.05.2021 |
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| Datum sprejetja članka: | 04.10.2021 |
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| Datum objave: | 14.10.2021 |
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| Založnik: | Dovepress |
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| Leto izida: | 2021 |
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| Št. strani: | Str. 4359-4369 |
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| Številčenje: | Letn. 15 |
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| PID: | 20.500.12556/DKUM-91070  |
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| UDK: | 616.36-006 |
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| COBISS.SI-ID: | 83680515 |
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| DOI: | 10.2147/DDDT.S255582 |
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| ISSN pri članku: | 1177-8881 |
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| Datum objave v DKUM: | 18.10.2024 |
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| Število ogledov: | 150 |
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| Število prenosov: | 11 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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