| Title: | Meta-analytic comparison of global RNA transcriptomes of acute and chronic myeloid leukemia cells reveals novel gene candidates governing myeloid malignancies |
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| Authors: | ID Jurgec, Staša (Author)
ID Jezernik, Gregor (Author)
ID Gorenjak, Mario (Author)
ID Büdefeld, Tomaž (Author)
ID Potočnik, Uroš (Author) |
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| Files: |  Jurgec_2022_Meta-Analytic_Comparison.pdf (1,04 MB)
MD5: BCFA9C4523D697EFD5CBB44F36CBF592
 https://doi.org/10.3390/cancers14194681
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | MF - Faculty of Medicine
FKKT - Faculty of Chemistry and Chemical Engineering
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| Abstract: | Despite advances in the understanding of genetic risk factors and molecular mechanisms underlying acute myeloid leukemia (AML) and chronic myeloid leukemia (CML), clinical outcomes of current therapies in terms of disease relapse and mortality rate pose a great economic and social burden. To overcome this, the identification of new molecular prognostic biomarkers and pharmacological targets is crucial. Recent studies have suggested that AML and CML may share common pathogenic mechanisms and cellular substrates. To this end, in the present study, global transcriptome profiles of AML and CML at the molecular and cellular level were directly compared using a combination of meta-analysis and modern statistics, and novel candidate genes and specific biological processes associated with the pathogenesis of AML and CML were characterized. Our study significantly improves our current understanding of myeloid leukemia and will help develop new therapeutic targets and biomarkers for disease progression, management and treatment response. |
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| Keywords: | AML, CML, meta-analysis, lincRNA, spliceosome |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 02.09.2022 |
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| Article acceptance date: | 22.09.2022 |
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| Publication date: | 26.09.2022 |
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| Publisher: | MDPI |
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| Year of publishing: | 2022 |
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| Number of pages: | Str. 1-16 |
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| Numbering: | Letn. 14, št. 19, št. članka 4681 |
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| PID: | 20.500.12556/DKUM-91259  |
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| UDC: | 616.155.392 |
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| ISSN on article: | 2072-6694 |
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| COBISS.SI-ID: | 123193347 |
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| DOI: | 10.3390/cancers14194681 |
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| Copyright: | © 2022 by the authors |
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| Publication date in DKUM: | 05.12.2024 |
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| Views: | 158 |
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| Downloads: | 13 |
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| Metadata: |    |
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| Categories: | Misc.
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