| Title: | Discovery of novel biomarkers with extended non-coding RNA interactor networks from genetic and protein biomarkers |
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| Authors: | ID Jezernik, Gregor (Author)
ID Glavač, Damjan (Author)
ID Skok, Pavel (Author)
ID Krušič, Martina (Author)
ID Potočnik, Uroš (Author)
ID Gorenjak, Mario (Author) |
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| Files: |  RAZ_Jezernik_Gregor_2024.pdf (9,14 MB)
MD5: D4D88D708FFA7CC31B7F1CF0701AACFE
 https://doi.org/10.3390/ijms251810210
https://www.mdpi.com/1422-0067/25/18/10210
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | MF - Faculty of Medicine
FKKT - Faculty of Chemistry and Chemical Engineering
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| Abstract: | Curated online interaction databases and gene ontology tools have streamlined the analysis of highly complex gene/protein networks. However, understanding of disease pathogenesis has gradually shifted from a protein-based core to complex interactive networks where non-coding RNA (ncRNA) is thought to play an essential role. As current gene ontology is based predominantly on protein-level information, there is a growing need to analyze networks with ncRNA. In this study, we propose a gene ontology workflow integrating ncRNA using the NPInter V5.0 database. To validate the proposed workflow, we analyzed our previously published curated biomarker datasets for hidden disease susceptibility processes and pharmacogenomics. Our results show a novel involvement of melanogenesis in psoriasis response to biological drugs in general. Hyperpigmentation has been previously observed in psoriasis following treatment with currently indicated biological drugs, thus calling attention to melanogenesis research as a response biomarker in psoriasis. Moreover, our proposed workflow highlights the need to critically evaluate computed ncRNA interactions within databases and a demand for gene ontology analysis of large miRNA blocks. |
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| Keywords: | gene ontology, non-coding RNA, ncRNA, disease pathogenesis, gene networks, protein networks, tools, psoriasis |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Article acceptance date: | 18.09.2024 |
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| Publication date: | 23.09.2024 |
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| Publisher: | MDPI |
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| Year of publishing: | 2024 |
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| Number of pages: | Str. 1-16 |
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| Numbering: | Letn. 25, Št. 18 |
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| PID: | 20.500.12556/DKUM-91274  |
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| UDC: | 575 |
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| ISSN on article: | 1422-0067 |
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| COBISS.SI-ID: | 208743939 |
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| DOI: | 10.3390/ijms251810210 |
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| Copyright: | © 2024 by the authors |
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| Publication date in DKUM: | 06.12.2024 |
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| Views: | 124 |
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| Downloads: | 23 |
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| Metadata: |    |
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| Categories: | Misc.
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