| Title: | Development of Biomimetic Sensors to Determine the Functionality of in Vitro Cell Models |
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| Authors: | ID Frangež, Matjaž (Author)
ID Glisik, Noah Emil (Author)
ID Kaiser, Maša (Author)
ID Vezjak, Jaro (Author)
ID Žnidaršič, Matic (Author)
ID Zidarič, Tanja (Author)
ID Maver, Tina (Author) |
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| Files: |  Development_of_biomimetic_sensors-Frangez-2024.pdf (999,07 KB)
MD5: 0DC348A3A1577E71B5D86F77CBA26788
 https://journals.um.si/index.php/anali-pazu/article/view/4803
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | MF - Faculty of Medicine
UZUM - University of Maribor Press
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| Abstract: | Advances in biomedical science have enabled the development of in vitro models that mimic human tissues. Non-invasive real-time monitoring of these models would provide valuable insights without disrupting the cellular environment. This study explores the use of molecularly imprinted polymers (MIPs) for this purpose, focusing on insulin and lactate as biomarkers of cellular metabolism. MIP sensors were created by electropolymerizing pyrrole around insulin or lactate templates on carbon electrodes. The sensors showed high sensitivity and selectivity, with detection ranges of 20.0–70.0 pM for insulin (LOD: 2.41 pM) and 0.5–3.0 mM for lactate. These findings highlight MIPs’ potential for personalized diagnostics and therapy monitoring. |
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| Keywords: | biomimetic sensors, molecular imprinting, polypyrrole matrix, insulin, MIP sensor |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 20.12.2024 |
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| Article acceptance date: | 09.10.2024 |
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| Publication date: | 23.12.2024 |
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| Place of publishing: | Maribor |
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| Publisher: | Univerza v Mariboru, Univerzitetna založba |
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| Year of publishing: | 2024 |
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| Number of pages: | 19 |
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| Numbering: | Letn.14, št.2 |
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| PID: | 20.500.12556/DKUM-91659  |
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| UDC: | 60 |
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| ISSN on article: | 2820-364X |
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| COBISS.SI-ID: | 223684355 |
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| DOI: | 10.18690/analipazu.14.2.39-57.2024 |
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| Publication date in DKUM: | 24.01.2025 |
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| Views: | 198 |
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| Downloads: | 32 |
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| Metadata: |    |
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| Categories: | Misc.
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