| Title: | Neurological outcome in patients after successful resuscitation in out-of-hospital settings |
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| Authors: | ID Marinšek, Martin (Author)
ID Sinkovič, Andreja (Author)
ID Šuran, David (Author) |
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| Files: |  Marinsek-2020-Neurological_outcome_in_patients.pdf (440,08 KB)
MD5: 9D2D49E754B0459CA9F356856AA1C0D2
 https://doi.org/10.17305/bjbms.2020.4623
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | MF - Faculty of Medicine
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| Abstract: | Neurological outcome is an important determinant of death in admitted survivors after out-of-hospital cardiac arrest (OHCA). Studies demonstrated several significant pre-hospital predictors of ischemic brain injury (time to resuscitation, time of resuscitation, and cause of OHCA). Our aim was to evaluate the relationship between post-resuscitation clinical parameters and neurological outcome in OHCA patients, when all recommended therapeutic strategies, including hypothermia, were on board. We retrospectively included consecutive 110 patients, admitted to the medical ICU after successful resuscitation due to OHCA. Neurological outcome was defined by cerebral performance category (CPC) scale I-V. CPC categories I-II defined good neurological outcome and CPC categories III-V severe ischemic brain injury. Therapeutic measures were aimed to achieve optimal circulation and oxygenation, early percutaneous coronary interventions (PCI) in acute coronary syndromes (ACS), and therapeutic hypothermia to improve survival and neurological outcome of OHCA patients. We observed good neurological outcome in 37.2% and severe ischemic brain injury in 62.7% of patients. Severe ischemic brain injury was associated significantly with known pre-hospital data (older age, cause of OHCA, and longer resuscitations), but also with increased admission lactate, in-hospital complications (involuntary muscular contractions/seizures, heart failure, cardiogenic shock, acute kidney injury, and mortality), and inotropic and vasopressor support. Good neurological outcome was associated with early PCI, dual antiplatelet therapy, and better survival. We conclude that in OHCA patients, post-resuscitation early PCI and dual antiplatelet therapy in ACS were significantly associated with good neurological outcome, but severe ischemic brain injury was associated with several in-hospital complications and the need for vasopressor and inotropic support. |
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| Keywords: | out-of-hospital cardiac arrest, OHCA, ischemic brain injury, resuscitation |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 26.01.2020 |
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| Article acceptance date: | 22.02.2020 |
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| Publication date: | 03.08.2020 |
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| Publisher: | The Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
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| Year of publishing: | 2020 |
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| Number of pages: | Str. 389-395 |
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| Numbering: | Letn. 20, št. 3 |
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| PID: | 20.500.12556/DKUM-91719  |
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| UDC: | 616.12-008.315 |
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| ISSN on article: | 1840-4812 |
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| COBISS.SI-ID: | 6976063 |
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| DOI: | 10.17305/bjbms.2020.4623 |
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| Publication date in DKUM: | 30.01.2025 |
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| Views: | 201 |
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| Downloads: | 30 |
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| Metadata: |    |
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| Categories: | Misc.
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