| Naslov: | In silico characterization of sirtuins in acetic acid bacteria reveals a novel phylogenetically distinctive group |
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| Avtorji: | ID Jugović, Igor (Avtor)
ID Trček, Janja (Avtor) |
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| Datoteke: |  RAZ_Jugovic_Igor_2025.pdf (9,06 MB)
MD5: C8FABB0F0279B67C163B39A5FFFF0C2D
 https://www.mdpi.com/1420-3049/30/3/635
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Znanstveno delo |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | FNM - Fakulteta za naravoslovje in matematiko
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| Opis: | Acetic acid bacteria are single-celled organisms well-known for their ability to convert ethanol into acetic acid. Still, recent research suggests they may harbor another attractive characteristic - the production of proteins with remarkable similarities to sirtuins. Sirtuins have been linked to lifespan extension in various organisms, raising intriguing questions about the potential connection between acetic acid bacteria and the biology of aging. This article delves into the characterization of sirtuin homologs in acetic acid bacteria. Up to three types of sirtuin homologs have been identified in 21% of acetic acid bacteria genomes deposited in NCBI. All three types were present only in the genera Acetobacter and Novacetimonas, which are known to survive in the harshest environmental conditions (high concentrations of acetic acid and ethanol). Interestingly, two types of these sirtuin homologs (SirAAB-L and SirAAB-S) constitute a separate group (SirAAB), distinctive from all other presently known sirtuins. The results obtained in silico thus encourage further studies into the function of these types of sirtuins and their interplay with metabolic pathways in these industrially important bacteria. |
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| Ključne besede: | acetic acid bacteria, Acetobacter, Novacetimonas, aging, sirtuins, SirAAB, SirAAB-L, SirAAB-S |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 23.08.2024 |
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| Datum sprejetja članka: | 28.01.2025 |
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| Datum objave: | 31.01.2025 |
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| Leto izida: | 2025 |
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| Št. strani: | str. 1-27 |
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| Številčenje: | Letn. 30, št. 3, št. članka 635 |
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| PID: | 20.500.12556/DKUM-91855  |
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| UDK: | 579.6 |
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| COBISS.SI-ID: | 225796099 |
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| DOI: | 10.3390/molecules30030635 |
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| ISSN pri članku: | 1420-3049 |
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| Datum objave v DKUM: | 14.02.2025 |
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| Število ogledov: | 252 |
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| Število prenosov: | 15 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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