| Title: | In silico characterization of sirtuins in acetic acid bacteria reveals a novel phylogenetically distinctive group |
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| Authors: | ID Jugović, Igor (Author)
ID Trček, Janja (Author) |
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| Files: |  RAZ_Jugovic_Igor_2025.pdf (9,06 MB)
MD5: C8FABB0F0279B67C163B39A5FFFF0C2D
 https://www.mdpi.com/1420-3049/30/3/635
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FNM - Faculty of Natural Sciences and Mathematics
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| Abstract: | Acetic acid bacteria are single-celled organisms well-known for their ability to convert ethanol into acetic acid. Still, recent research suggests they may harbor another attractive characteristic - the production of proteins with remarkable similarities to sirtuins. Sirtuins have been linked to lifespan extension in various organisms, raising intriguing questions about the potential connection between acetic acid bacteria and the biology of aging. This article delves into the characterization of sirtuin homologs in acetic acid bacteria. Up to three types of sirtuin homologs have been identified in 21% of acetic acid bacteria genomes deposited in NCBI. All three types were present only in the genera Acetobacter and Novacetimonas, which are known to survive in the harshest environmental conditions (high concentrations of acetic acid and ethanol). Interestingly, two types of these sirtuin homologs (SirAAB-L and SirAAB-S) constitute a separate group (SirAAB), distinctive from all other presently known sirtuins. The results obtained in silico thus encourage further studies into the function of these types of sirtuins and their interplay with metabolic pathways in these industrially important bacteria. |
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| Keywords: | acetic acid bacteria, Acetobacter, Novacetimonas, aging, sirtuins, SirAAB, SirAAB-L, SirAAB-S |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 23.08.2024 |
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| Article acceptance date: | 28.01.2025 |
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| Publication date: | 31.01.2025 |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-27 |
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| Numbering: | Letn. 30, št. 3, št. članka 635 |
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| PID: | 20.500.12556/DKUM-91855  |
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| UDC: | 579.6 |
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| ISSN on article: | 1420-3049 |
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| COBISS.SI-ID: | 225796099 |
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| DOI: | 10.3390/molecules30030635 |
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| Publication date in DKUM: | 14.02.2025 |
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| Views: | 254 |
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| Downloads: | 15 |
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| Metadata: |    |
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| Categories: | Misc.
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