| Title: | Experimental investigation of the biofunctional properties of nickel–titanium alloys depending on the type of production |
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| Authors: | ID Miličić Lazić, Minja (Author)
ID Majerič, Peter (Author)
ID Lazić, Vojkan (Author)
ID Milašin, Jelena (Author)
ID Jakšić, Milica (Author)
ID Trišić, Dijana (Author)
ID Radović, Katarina (Author) |
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| Files: |  molecules-27-01960-v2.pdf (3,07 MB)
MD5: 01451FDA25786C7E093F82B244B16638
 https://www.mdpi.com/1420-3049/27/6/1960
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FS - Faculty of Mechanical Engineering
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| Abstract: | Nickel–titanium alloys used in dentistry have a variety of mechanical, chemical, and
biofunctional properties that are dependent on the manufacturing process. The aim of this study
was to compare the mechanical and biofunctional performances of a nickel–titanium alloy produced
by the continuous casting method (NiTi-2) with commercial nitinol (NiTi-1) manufactured by the
classical process, i.e., from remelting in a vacuum furnace with electro-resistive heating and final
casting into ingots. The chemical composition of the tested samples was analyzed using an energy
dispersive X-ray analysis (EDX) and X-ray fluorescence (XRF). Electron backscatter diffraction (EBSD)
quantitative microstructural analysis was performed to determine phase distribution in the samples.
As part of the mechanical properties, the hardness on the surface of samples was measured with
the static Vickers method. The release of metal ions (Ni, Ti) in artificial saliva (pH 6.5) and lactic
acid (pH 2.3) was measured using a static immersion test. Finally, the resulting corrosion layer was
revealed by means of a scanning electron microscope (SEM), which allows the detection and direct
measurement of the formatted oxide layer thickness. To assess the biocompatibility of the tested
nickel–titanium alloy samples, an MTT test of fibroblast cellular proliferation on direct contact with
the samples was performed. The obtained data were analyzed with the IBM SPSS Statistics v22
software. EDX and XRF analyses showed a higher presence of Ni in the NiTi-2 sample. The EBSD
analysis detected an additional NiTi2
-cubic phase in the NiTi-2 microstructure. Additionally, in the
NiTi-2 higher hardness was measured. An immersion test performed in artificial saliva after 7 days
did not induce significant ion release in either group of samples (NiTi-1 and NiTi-2). The acidic
environment significantly increased the release of toxic ions in both types of samples. However, Ni
ion release was two times lower, and Ti ion release was three times lower from NiTi-2 than from
NiTi-1. Comparison of the cells’ mitochondrial activity between the NiTi-1 and NiTi-2 groups did
not show a statistically significant difference. In conclusion, we obtained an alloy of small diameter
with an appropriate microstructure and better response compared to classic NiTi material. Thus, it
appears from the present study that the continuous cast technology offers new possibilities for the
production of NiTi material for usage in dentistry. |
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| Keywords: | nickel–titanium, continuous casting, characterization, biofunctional properties, biocompatibility |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 29.01.2022 |
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| Article acceptance date: | 15.03.2022 |
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| Publication date: | 17.03.2022 |
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| Publisher: | MDPI AG |
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| Year of publishing: | 2022 |
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| Number of pages: | 14 str. |
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| Numbering: | Vol. 27, iss. 6 (1960) |
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| PID: | 20.500.12556/DKUM-92242  |
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| UDC: | 621.74:620.1 |
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| ISSN on article: | 1420-3049 |
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| COBISS.SI-ID: | 102129923 |
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| DOI: | 10.3390/molecules27061960 |
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| Copyright: | © 2022 by the authors. |
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| Publication date in DKUM: | 24.03.2025 |
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| Views: | 144 |
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| Downloads: | 5 |
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| Metadata: |    |
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| Categories: | Misc.
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