| Naslov: | Ranking as a procedure for selecting a replacement variable in the score predicting the survival of patients treated with curative intent for colorectal liver metastases |
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| Avtorji: | ID Plahuta, Irena (Avtor)
ID Mencinger, Matej (Avtor)
ID Peruš, Iztok (Avtor)
ID Magdalenić, Tomislav (Avtor)
ID Turk, Špela (Avtor)
ID Brumec, Aleks (Avtor)
ID Potrč, Stojan (Avtor)
ID Ivanecz, Arpad (Avtor) |
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| Datoteke: |  Plahuta_2023_Ranking_as_a_Procedure_for_Selecting.pdf (1,15 MB)
MD5: BEAB34B7FCC5601FBBD5335702F8BEB4
 https://doi.org/10.3390/medicina59112003
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Znanstveno delo |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | MF - Medicinska fakulteta
FGPA - Fakulteta za gradbeništvo, prometno inženirstvo in arhitekturo
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| Opis: | Background and Objectives: The issue of a missing variable precludes the external validation of many prognostic models. For example, the Liverpool score predicts the survival of patients undergoing surgical therapy for colorectal liver metastases, but it includes the neutrophil–lymphocyte ratio, which cannot be measured retrospectively.
Materials and Methods: We aimed to find the most appropriate replacement for the neutrophil–lymphocyte ratio. Survival analysis was performed on data representing 632 liver resections for colorectal liver metastases from 2000 to 2020. Variables associated with the Liverpool score, C-reactive protein, albumins, and fibrinogen were ranked. The rankings were performed in four ways: The first two were based on the Kaplan-Meier method (log-rank statistics and the definite integral ��
between two survival curves). The next method of ranking was based on univariate and multivariate Cox regression analyses.
Results: The ranks were as follows: the radicality of liver resection (rank 1), lymph node infiltration of primary colorectal cancer (rank 2), elevated C-reactive protein (rank 3), the American Society of Anesthesiologists Classification grade (rank 4), the right-sidedness of primary colorectal cancer (rank 5), the multiplicity of colorectal liver metastases (rank 6), the size of colorectal liver metastases (rank 7), albumins (rank 8), and fibrinogen (rank 9).
Conclusions: The ranking methodologies resulted in almost the same ranking order of the variables. Elevated C-reactive protein was ranked highly and can be considered a relevant replacement for the neutrophil–lymphocyte ratio in the Liverpool score. These methods are suitable for ranking variables in similar models for medical research. |
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| Ključne besede: | colorectal cancer, liver metastases, inflammation, ranking, survival |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 16.10.2023 |
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| Datum sprejetja članka: | 13.11.2023 |
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| Datum objave: | 15.11.2023 |
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| Založnik: | MDPI |
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| Leto izida: | 2023 |
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| Št. strani: | Str. 1-13 |
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| Številčenje: | Letn. 59, št. 1, št. članka 2003 |
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| PID: | 20.500.12556/DKUM-92421  |
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| UDK: | 616.36-006 |
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| COBISS.SI-ID: | 172746243 |
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| DOI: | 10.3390/medicina59112003 |
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| ISSN pri članku: | 1648-9144 |
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| Datum objave v DKUM: | 07.04.2025 |
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| Število ogledov: | 174 |
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| Število prenosov: | 24 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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