| Naslov: | Surface and subsurface mass spectrometric analysis of dexamethasone in solid pharmaceutical dosage forms |
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| Avtorji: | ID Finšgar, Matjaž (Avtor) |
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| Datoteke: |  Journal_of_Mass_Spectrometry_-_2025_-_Finsgar_-_Surface_and_Subsurface_Mass_Spectrometric_Analysis_of_Dexamethasone_in.pdf (5,53 MB)
MD5: 1006D2650BF3F3FF64B6E7EBF84D3798
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Članek v reviji |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | FKKT - Fakulteta za kemijo in kemijsko tehnologijo
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| Opis: | This study presents an in-depth mass spectrometric investigation of dexamethasone (DEX) distribution within pharmaceutical tablets using time-of-flight secondary ion mass spectrometry (ToF-SIMS) combined with gas cluster ion beam (GCIB) sputtering. Fragmentation mechanism of DEX was identified, which enabled the determination of three-dimensional chemical imaging of the active ingredient in both surface and subsurface regions. The data reveal that a 4-mg DEX formulation exhibits a continuous and extended distribution of the drug into the tablet matrix, while a 0.5-mg formulation shows DEX localized in distinct, isolated domains. Topographical features and the overall composition of the surface were confirmed by complementary analyses employing atomic force microscopy (AFM) and x-ray photoelectron spectroscopy (XPS). These results demonstrate how molecule distribution patterns can be linked to formulation heterogeneity using advanced mass spectrometric techniques, opening new possibilities for pharmaceutical manufacturing quality control and optimization. |
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| Ključne besede: | mass spectrometry, dexamethasone, pharmaceutical tablets, DEX, ToF-SIMS |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 08.05.2025 |
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| Datum sprejetja članka: | 13.05.2025 |
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| Datum objave: | 18.05.2025 |
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| Založnik: | Wiley |
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| Leto izida: | 2025 |
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| Št. strani: | 11 str. |
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| PID: | 20.500.12556/DKUM-93001  |
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| UDK: | 66 |
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| COBISS.SI-ID: | 236328963 |
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| DOI: | 10.1002/jms.5147 |
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| ISSN pri članku: | 1096-9888 |
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| Avtorske pravice: | © 2025 The Author(s) |
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| Datum objave v DKUM: | 30.05.2025 |
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| Število ogledov: | 267 |
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| Število prenosov: | 8 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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