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Title:Razvoj aerogelov na osnovi hitozana: vsestranski pristop za različne aplikacije : magistrsko delo
Authors:ID Martinuzzi, Jure (Author)
ID Novak, Zoran (Mentor) More about this mentor... New window
ID Pantić, Milica (Comentor)
Files:.pdf MAG_Martinuzzi_Jure_2025.pdf (3,26 MB)
MD5: F3232B000DD8A7632FA6E7606EBA1D26
 
Language:Slovenian
Work type:Master's thesis/paper
Typology:2.09 - Master's Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:V magistrskem delu prikazujemo razvoj kompozitnih polisaharidnih aerogelov na osnovi hitozana, pri čemer kot dodatna biopolimera uporabljamo pektin in ksantan. Osredotočamo se na vpliv razmerij med posameznimi polisaharidi, strukturne lastnosti in termično stabilnost nastalih polisaharidnih aerogelov. Takšni aerogeli so zaradi biokompatibilnosti, razgradljivosti in vsestranskih funkcionalnih lastnosti perspektivni za uporabo v različnih biomedicinskih aplikacijah. Za pripravo pektin-hitozanskih in ksantan-hitozanskih aerogelov uporabljamo sol-gel sintezo, pri čemer spreminjamo volumenska razmerja uporabljenih polisaharidov. Nastale alkogele sušimo s superkritičnim ogljikovim dioksidom pod različnimi pogoji: pri 40 °C in 120 barih ob prisotnosti etanola na polindustrijski napravi UHDE ter 40 °C in 200 barih brez etanola na napravi Extrate X SFE 500. Dobljene vzorce podrobno karakteriziramo z različnimi metodami, kot so plinska adsorpcija, Fourierjeva transformacijska infrardeča spektroskopija (FTIR), tremogravimetrična analiza (TGA) in diferencialna vrstična kalorimetrija (DSC). Poleg tega izvajamo tudi teste nabrekanja, s katerimi preučimo obnašanje aerogelov v mediju fosfatnega pufra. Izbrane polisaharidne aerogele impregniramo z natrijevim diklofenakom in ovrednotimo vpliv impregnacije na strukturne in termične lastnosti. Rezultati kažejo, da na končne lastnosti kompozitnih polisaharidnih aerogelov pomembno vplivajo tako razmerja polisaharidov kot tudi pogoji sušenja in prisotnost izbrane zdravilne učinkovine.
Keywords:Polisaharidni aerogeli, hitozan, pektin, ksantan, superkritični fluidi
Place of publishing:Maribor
Place of performance:Maribor
Publisher:[J. Martinuzzi]
Year of publishing:2025
Number of pages:1 spletni vir (1 datoteka PDF (XI, 62 str.))
PID:20.500.12556/DKUM-93676 New window
UDC:544.774.2:547.458(043.2)
COBISS.SI-ID:261092611 New window
Publication date in DKUM:04.11.2025
Views:176
Downloads:52
Metadata:XML DC-XML DC-RDF
Categories:KTFMB - FKKT
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Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:10.08.2025

Secondary language

Language:English
Title:Development of chitosan-based aerogels: a versatile approach for various applications
Abstract:This master’s thesis presents the development of composite polysaccharide aerogels based on chitosan, incorporating pectin and xanthan as additional biopolymers. The research focuses on the influence of the ratios between individual polysaccharides on the structural properties and thermal stability of the resulting aerogels. Due to their biocompatibility, biodegradability, and versatile functional properties, such aerogels are considered promising candidates for various biomedical applications. Pectin-chitosan and xanthan-chitosan aerogels are prepared via sol–gel synthesis, varying the volume ratios of the polysaccharides used. The resulting alcogels are dried with supercritical carbon dioxide under different conditions: at 40 °C and 120 bar in the presence of ethanol using a semi-industrial UHDE apparatus, and at 40 °C and 200 bar without ethanol using the Extrate X SFE 500 system. The obtained samples are thoroughly characterized using several analytical techniques, including gas adsorption, Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). In addition, swelling tests are performed to investigate the behaviour of the aerogels in a phosphate buffer medium. Selected polysaccharide aerogels are impregnated with sodium diclofenac, and the effect of impregnation on their structural and thermal properties is evaluated. The results demonstrate that the final properties of the composite polysaccharide aerogels are significantly influenced by the polysaccharide ratios, drying conditions, and the presence of the chosen active pharmaceutical ingredient.
Keywords:Polysaccharide aerogels, chitosan, pectin, xanthan, supercritical fluids


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