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Title:CFD simulacija polnjenja vijale s suspenzijo deformabilnih delcev : magistrsko delo
Authors:ID Harl, Nika (Author)
ID Hriberšek, Matjaž (Mentor) More about this mentor... New window
Files:.pdf MAG_Harl_Nika_2025.pdf (3,54 MB)
MD5: C0F57694BCC303292A7EBD144F4CFC93
 
Language:Slovenian
Work type:Master's thesis/paper
Typology:2.09 - Master's Thesis
Organization:FS - Faculty of Mechanical Engineering
Abstract:V magistrskem delu je predstavljena numerična analiza procesa polnjenja farmacevtske vijale s suspenzijo, ki vsebuje enkrat nedeformabilne in drugič deformabilne mikrodelce. Glavni cilj simulacij je bil preučiti dinamiko tokovnega polja ter vpliv polnilnega procesa na gibanje in deformacijo delcev v tekočini. Uporabljena je bila metoda VOF za sledenje proste gladine med zrakom in vodo, dopolnjena z Lagrangevim pristopom za sledenje delcev. Porazdelitev nedeformabilnih ter deformabilnih delcev med in po polnjenju je zelo podobna, prav tako učinek usedanja. Rezultati pokažejo, da polnjenje vijale večinoma ni kritičen del proizvodnega procesa takšnih zdravil, saj so deformacije delcev minimalne.
Keywords:računalniška dinamika tekočin (CFD), VOF metoda, Lagrangevo sledenje delcev, deformabilni mikrodelci
Place of publishing:Maribor
Place of performance:Maribor
Publisher:[N. Harl]
Year of publishing:2025
Number of pages:1 spletni vir (1 datoteka PDF (XV, 61 f.))
PID:20.500.12556/DKUM-94078 New window
UDC:532:519.6(043.2)
COBISS.SI-ID:248964355 New window
Publication date in DKUM:22.08.2025
Views:257
Downloads:87
Metadata:XML DC-XML DC-RDF
Categories:KTFMB - FS
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Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:30.07.2025

Secondary language

Language:English
Title:CFD simulation of vial filling with suspension of deformable particles
Abstract:The master's thesis presents a numerical analysis of the process of a pharmaceutical vial filling with a suspension containing non-deformable and deformable microparticles. The main objective of the simulations was to study the flow field dynamics and the effect of the filling process on the motion and deformation of particles in the fluid. The VOF method was used to track the free surface between air and water, supplemented by the Lagrangian approach for particle tracking. The distribution of non-deformable and deformable particles during and after filling is very similar, as is the effect of sedimentation. The results indicate that the vial filling process is generally not a critical stage of the production process for such pharmaceutical products, as particle deformations are minimal.
Keywords:computational fluid dynamics (CFD), VOF method, Lagrangian particle tracking, deformable microparticles


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