| Naslov: | Surface analysis of sodium metamizolate as an active pharmaceutical ingredient in solid form |
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| Avtorji: | ID Finšgar, Matjaž (Avtor)
ID Varda, Katja Andrina (Avtor) |
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| Datoteke: |  1-s2.0-S1387380625001526-main.pdf (9,03 MB)
MD5: 119AA6E41FD06A48BCEF2DBEA5951777
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Članek v reviji |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | FKKT - Fakulteta za kemijo in kemijsko tehnologijo
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| Opis: | This study focuses on the surface and subsurface characterization of a pharmaceutical tablet containing sodium metamizolate (NaMET), with an emphasis on mass spectrometry using time-of-flight secondary ion mass spectrometry (ToF-SIMS). ToF-SIMS enabled the identification of NaMET-specific fragment ions, which served as signals for the determination of the spatial distribution of this active pharmaceutical ingredient (API) within the tablet matrix. A ToF-SIMS fragmentation mechanism for NaMET was proposed based on the ToF-SIMS spectra analysis measured on a NaMET reference standard. 3D ToF-SIMS imaging showed heterogeneous localization of the API across a 5 μm depth. Complementary techniques, including 3D profilometry and atomic force microscopy (AFM), provided surface roughness and morphological data, while X-ray photoelectron spectroscopy (XPS) confirmed the elemental composition and chemical states. Depth profiling by XPS further supported the non-uniform distribution of NaMET. |
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| Ključne besede: | matamizole, sodium metamizolate, ToF-SIMS, XPS, surface analysis, API |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 15.07.2025 |
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| Datum sprejetja članka: | 29.10.2025 |
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| Datum objave: | 05.11.2025 |
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| Založnik: | Elsevier B. V. |
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| Leto izida: | 2026 |
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| Št. strani: | 10 str. |
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| Številčenje: | Vol. 519, [article no.] 117548 |
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| PID: | 20.500.12556/DKUM-95915  |
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| UDK: | 661.12:615 |
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| COBISS.SI-ID: | 256060931 |
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| DOI: | 10.1016/j.ijms.2025.117548 |
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| ISSN pri članku: | 1873-2798 |
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| Avtorske pravice: | © 2025 The Authors |
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| Datum objave v DKUM: | 10.11.2025 |
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| Število ogledov: | 167 |
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| Število prenosov: | 14 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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