| Title: | Surface analysis of sodium metamizolate as an active pharmaceutical ingredient in solid form |
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| Authors: | ID Finšgar, Matjaž (Author)
ID Varda, Katja Andrina (Author) |
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| Files: |  1-s2.0-S1387380625001526-main.pdf (9,03 MB)
MD5: 119AA6E41FD06A48BCEF2DBEA5951777
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FKKT - Faculty of Chemistry and Chemical Engineering
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| Abstract: | This study focuses on the surface and subsurface characterization of a pharmaceutical tablet containing sodium metamizolate (NaMET), with an emphasis on mass spectrometry using time-of-flight secondary ion mass spectrometry (ToF-SIMS). ToF-SIMS enabled the identification of NaMET-specific fragment ions, which served as signals for the determination of the spatial distribution of this active pharmaceutical ingredient (API) within the tablet matrix. A ToF-SIMS fragmentation mechanism for NaMET was proposed based on the ToF-SIMS spectra analysis measured on a NaMET reference standard. 3D ToF-SIMS imaging showed heterogeneous localization of the API across a 5 μm depth. Complementary techniques, including 3D profilometry and atomic force microscopy (AFM), provided surface roughness and morphological data, while X-ray photoelectron spectroscopy (XPS) confirmed the elemental composition and chemical states. Depth profiling by XPS further supported the non-uniform distribution of NaMET. |
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| Keywords: | matamizole, sodium metamizolate, ToF-SIMS, XPS, surface analysis, API |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 15.07.2025 |
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| Article acceptance date: | 29.10.2025 |
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| Publication date: | 05.11.2025 |
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| Publisher: | Elsevier B. V. |
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| Year of publishing: | 2026 |
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| Number of pages: | 10 str. |
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| Numbering: | Vol. 519, [article no.] 117548 |
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| PID: | 20.500.12556/DKUM-95915  |
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| UDC: | 661.12:615 |
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| ISSN on article: | 1873-2798 |
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| COBISS.SI-ID: | 256060931 |
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| DOI: | 10.1016/j.ijms.2025.117548 |
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| Copyright: | © 2025 The Authors |
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| Publication date in DKUM: | 10.11.2025 |
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| Views: | 169 |
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| Downloads: | 14 |
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| Metadata: |    |
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| Categories: | Misc.
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