| Title: | From surface to core : comprehensive ToF-SIMS insights into pharmaceutical tablet analysis |
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| Authors: | ID Finšgar, Matjaž (Author) |
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| Files: |  1-s2.0-S0026265X24009470-main.pdf (6,25 MB)
MD5: 56A607BD325B45B531F4F029D63E05E7
 https://www.sciencedirect.com/science/article/pii/S0026265X24009470?via%3Dihub#da005
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FKKT - Faculty of Chemistry and Chemical Engineering
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| Abstract: | This study presents an innovative approach to pharmaceutical analysis using time-of-flight secondary ion mass spectrometry (ToF-SIMS) to investigate tablets containing paracetamol in the solid state without the need for traditional pretreatment methods (dissolution, filtration, etc.). Employing both MS1 and MS2 ToF-SIMS spectra, signals characteristic of paracetamol and a fragmentation mechanism were assigned. Some findings challenge previous interpretations of certain ToF-SIMS signals attributed to paracetamol, highlighting the need for reevaluation. Moreover, as the sample was used without any pretreatment (a purchased tablet), which has a complex matrix, the resulting ToF-SIMS mass spectra can suffer from spectral interferences. The use of multivariate statistical analysis resulted in the assignment of unique signals for paracetamol. Additionally, ToF-SIMS imaging was utilized with high mass and lateral resolution, employing the delayed-extraction ToF analyzer mode, to image the two-dimensional distribution of species on the tablet’s surface with an emphasis on paracetamol distribution. The use of a gas cluster ion beam (GCIB) sputtering source in association with ToF-SIMS enabled the visualization of the three–dimensional distribution of species within the tablet. This thorough investigation advances knowledge regarding the characterization of paracetamol and offers the examination of pharmaceuticals without sample pretreatment with elemental and molecular-specific information. |
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| Keywords: | 2D and 3D imaging, mass spectrometry, tandem MS/MS, paracetamol, ToF-SIMS |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 17.03.2024 |
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| Article acceptance date: | 20.05.2024 |
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| Publication date: | 22.05.2024 |
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| Publisher: | Elsevier |
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| Year of publishing: | 2024 |
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| Number of pages: | 9 str. |
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| Numbering: | Vol. 202, [article no.] 110835 |
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| PID: | 20.500.12556/DKUM-96773  |
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| UDC: | 544.5/.6 |
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| ISSN on article: | 1095-9149 |
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| COBISS.SI-ID: | 196997123 |
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| DOI: | 10.1016/j.microc.2024.110835 |
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| Copyright: | © 2024 The Author(s) |
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| Publication date in DKUM: | 28.01.2026 |
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| Views: | 233 |
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| Downloads: | 2 |
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| Metadata: |    |
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| Categories: | Misc.
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