| Naslov: | Symmetry-induced maximum entropy production in enzyme kinetics : a noether-type mechanism |
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| Avtorji: | ID Dobovišek, Andrej (Avtor)
ID Fajmut, Aleš (Avtor) |
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| Datoteke: |  RAZ_Dobovisek_Andrej_2026.htm (143,53 KB)
MD5: 76F0DB4F3A17CBBC8DEC8979BFD37460
https://doi.org/10.1016/j.physa.2026.131366
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Znanstveno delo |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | FNM - Fakulteta za naravoslovje in matematiko
FZV - Fakulteta za zdravstvene vede
MF - Medicinska fakulteta
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| Opis: | We investigate the maximum entropy production principle (MEPP) in a minimal two-state enzymatic cycle at a nonequilibrium steady state. Using master-equation kinetics, we show that maximal entropy production arises not by explicit extremization but from internal kinetic constraints together with statistically symmetric occupancy of enzyme states. Under these conditions, the Briggs-Haldane steady-state flux equals the structural upper limit set by the catalytic scheme, while the total thermodynamic force is a constant determined solely by intrinsic unimolecular rates. At the microscopic level, a uniform distribution over configurations admits a Lie group of infinitesimal rotations that leave the probability distribution, flux, and force invariant; hence the entropy-production functional is invariant. This yields a Noether-type interpretation of MEPP: maximal entropy production is a structural invariant of an internally organized enzymatic cycle, rather than an externally imposed variational optimum. |
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| Ključne besede: | nonequilibrium steady state, entropy production, Shannon entropy, enzyme kinetics, noether-type symmetry |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 09.02.2026 |
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| Leto izida: | 2026 |
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| Št. strani: | 12 str. |
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| Številčenje: | Letn. 686, št. članka 131366 |
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| PID: | 20.500.12556/DKUM-97049  |
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| UDK: | 536.7:530.145:577.152 |
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| COBISS.SI-ID: | 268368131 |
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| DOI: | 10.1016/j.physa.2026.131366 |
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| ISSN pri članku: | 0378-4371 |
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| Datum objave v DKUM: | 13.02.2026 |
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| Število ogledov: | 162 |
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| Število prenosov: | 11 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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