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Title:Sinteza aktivnih komponent za zdravila z gensko spremenjenimi rastlinami
Authors:ID Luthar, Zlata (Author)
Files:.pdf Sinteza_aktivnih_komponent-Luthar-2017.pdf (629,21 KB)
MD5: C28B3F3C12E65F6B021B029E549DB720
 
URL https://journals.um.si/index.php/anali-pazu/article/view/1989
 
Language:Slovenian
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:UZUM - University of Maribor Press
Abstract:V zadnjih letih so izsledki na področju kliničnih testiranj rekombinantnih zdravil pridobljenih z gensko spremenjenimi (GS) rastlinami doživeli velik razcvet. V ta namen so bili uspešno opravljeni številni poskusi povečanja izražanja antigenov za zdravljenje nalezljivih virusnih in bakterijskih bolezni. Najnovejše raziskave so osredotočene v optimizacijo sinteze in pridobivanja antigenov za zdravljenje avtoimunih in genetskih bolezni. Razmišlja pa se tudi v smer sinteze antigenov za zdravljenje tropskih bolezni. Vedno več je izsledkov o uporabi zdravil z zaužitjem svežega rastlinskega materiala (predvsem v veterini). Komponentna cepiva pridobljena z GS rastlinami so sposobna vzbuditi močnejši imunski odziv in izzvati imunski spomin za daljše časovno obdobje. Njihovo pridobivanje je povezano z manjšimi proizvodnimi stroški. Kljub vsem raziskavam in dosežkom pa nobeno od zdravil pridobljeno z GS rastlinami ni prisotno na trgu. Za dosego tega bo potrebno odpraviti težave povezane s proizvodnjo, uporabo, predvsem pa z biološko varnostjo in splošnim mnenjem javnosti do GS rastlin.
Keywords:sinteza, rekombinantni proteini, antigeni, zdravljenje, imunski odziv, imunski spomin, gensko spremenjene rastline
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2017
Place of publishing:Maribor
Publisher:Univerza v Mariboru, Univerzitetna založba
Year of publishing:2017
Number of pages:10
Numbering:Letn.7, št.1/2
PID:20.500.12556/DKUM-97315 New window
UDC:606:61
ISSN on article:2820-364X
COBISS.SI-ID:299471360 New window
DOI:10.18690/analipazu.7.1-2.36-45.2017 New window
Publication date in DKUM:27.02.2026
Views:161
Downloads:6
Metadata:XML DC-XML DC-RDF
Categories:Misc.
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Record is a part of a journal

Title:Anali PAZU
Publisher:Združenje Pomurska akademsko znanstvena unija, Združenje Pomurska akademsko znanstvena unija, Univerzitetna založba Univerze v Mariboru
ISSN:2232-416X
COBISS.SI-ID:257553152 New window

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

Language:English
Title:Synthesis of Active Ingredients for Medicines by Genetically Modified Plants
Abstract:In recent years, the findings in clinical trials of recombinant medicines derived from genetically modified (GM) plants boomed. For these purposes, some numerous attempts to increase expression of antigens for the treatment of infectious viral and bacterial diseases have been successfully carried out. In recent times, research has focused on optimizing the synthesis and extraction of antigens for the treatment of autoimmune and genetic diseases. It is also considered in the direction of the synthesis of the antigens for the treatment of tropical diseases. The development is focused on the use of medicines with the consumption of fresh plant material (especially in veterinary medicine). Component vaccines derived from GM plants can arouse a stronger immune response and immunological memory for a longer period. Their acquisition is related to lower production costs. Despite all the research and achievements, none of the medicines obtained by GM plants is present on the market. To achieve that it will be necessary to eliminate the problems associated with the production, use and particularly problems related to biosafety and the general public's perception of GM plants.
Keywords:genetically modified plants, synthesis, recombinant proteins, antigens, healing, immune response, immunological memory


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  1. Anali PAZU

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