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Title:Sinteza encima ß-glukozidaze v semenih transgenega riža za nadomestno zdravljenje dedne Gaucherjeve bolezni
Authors:ID Luthar, Zlata (Author)
Files:.pdf Sinteza_encima-Luthar-2016.pdf (1,16 MB)
MD5: 6135FD800E52B05621A19AB59367CD69
 
URL https://journals.um.si/index.php/anali-pazu/article/view/1983
 
Language:Slovenian
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:UZUM - University of Maribor Press
Abstract:Pridobivanje aktivnih sestavin za zdravila, predvsem cepiva s transgenimi rastlinami se je začelo pred 25 leti. Zaradi določenih prednosti sinteze učinkovin s transgenimi rastlinami, v primerjavi z obstoječim pridobivanjem, se vse bolj uveljavljajo optimizirani transformacijski in ekspresijski sistemi ter njihova uporaba. Do sedaj je bilo v ospredju pridobivanje učinkovin za preventivo in zdravljenje številnih nalezljivih človeških in živalskih bolezni. V zadnjem obdobju je vse več primerov pridobivanja rekombinantnih proteinov za zdravljenje avtoimunskih in genetskih obolenj. Med temi je tudi zelo redka Gaucherjeva bolezen, pomanjkanje encima glukocerebrozidaze, ki jo lahko zdravimo z nadomestnim encimom β-glukozidazo. Transgeni riž uspešno sintetizira in nalaga β-glukozidazo v endosperm v obdobju formiranja in zorenja semen.
Keywords:transgeni riž, ß-glukozidaza, Gaucherjeva bolezen, sproščanje v okolje, tveganje, zakonodaja
Publication status:Published
Publication version:Version of Record
Publication date:01.11.2016
Place of publishing:Maribor
Publisher:Univerza v Mariboru, Univerzitetna založba
Year of publishing:2016
Number of pages:9
Numbering:Letn.6, št.1/2
PID:20.500.12556/DKUM-97344 New window
UDC:604
ISSN on article:2820-364X
COBISS.SI-ID:14717491 New window
DOI:10.18690/analipazu.6.1-2.20-28.2016 New window
Publication date in DKUM:02.03.2026
Views:170
Downloads:2
Metadata:XML DC-XML DC-RDF
Categories:Misc.
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Record is a part of a journal

Title:Anali PAZU
Publisher:Združenje Pomurska akademsko znanstvena unija, Združenje Pomurska akademsko znanstvena unija, Univerzitetna založba Univerze v Mariboru
ISSN:2232-416X
COBISS.SI-ID:257553152 New window

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

Language:English
Title:The Synthesis of the ß-Glucosidase Enzyme in the Transgenic Rice Seeds for Replacement Therapy of the Heritable Gaucher Disease
Abstract:Production of active ingredients for pharmaceuticals, especially vaccines with transgenic crops, began 25 years ago. Due to certain advantages of the synthesis of active transgenic crops ingredients, in comparison with the current production, the optimized transformation expression systems and their application are gaining ground. Until now, the focus has been on sourcing agents for preventing and treating a variety of infectious human and animal diseases. In recent years, there is an increasing number of cases including the acquiring of recombinant proteins for the treatment of autoimmune and genetic diseases, including the very rare Gaucher disease (lack an enzyme glucocerebrosidase), which can be treated with replacement enzyme β-glucosidase. Transgenic rice successfully synthesized and imposes β-glucosidase in the endosperm during the period of formation and maturation of seeds.
Keywords:transgenic rice, ß-glucosidase, Gaucher disease, reelase into the environment, risk, legislation


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  1. Anali PAZU

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