| Title: | Autophagy: the shared mechanism between fasting and phytocannabinoids |
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| Authors: | ID Meden, Vesna Mila (Author)
ID Bagar, Tanja (Author) |
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| Files: |  RAZ_Meden_Vesna_Mila_2026.pdf (822,73 KB)
MD5: A2C006B59592EF36E07D02877A3072BD
 https://journals.um.si/index.php/anali-pazu/article/view/6278
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FKBV - Faculty of Agriculture and Life Sciences
UZUM - University of Maribor Press
FNM - Faculty of Natural Sciences and Mathematics
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| Abstract: | Autophagy is a conserved cellular self-renewal process essential for maintaining metabolic balance and responding to physiological stress. Modern dietary patterns, characterized by frequent and excessive food intake, often disrupt these adaptive mechanisms and contribute to metabolic disorders. In contrast, humans evolved under conditions of intermittent food scarcity, during which fasting-induced autophagy provided a survival advantage. Fasting generates mild metabolic stress (hormesis) that activates cytoprotective pathways and enhances cellular resilience. Similarly, several plant-derived compounds, including phytocannabinoids, have been shown to modulate autophagy in both healthy and tumour cells. Emerging evidence indicates that cannabinoids predominantly promote autophagic activity, positioning them as potential modulators of cellular homeostasis. Understanding the shared mechanisms through which fasting and phytocannabinoids induce autophagy may help inform therapeutic strategies targeting metabolic dysregulation, inflammation, and disease progression. Coordinated, well-timed activation of autophagy may therefore offer promising avenues for health optimisation. |
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| Keywords: | autophagy, phytocannabinoids, fasting, cellular homeostasis, hormesis |
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| Publication status: | In print |
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| Publication version: | Version of Record |
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| Publication date: | 31.07.2026 |
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| Year of publishing: | 2026 |
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| Number of pages: | str. 21-34 |
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| Numbering: | Letn. 16, št. 1/2 |
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| PID: | 20.500.12556/DKUM-99467  |
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| UDC: | 613.24:616-092:576.311 |
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| ISSN on article: | 2232-416X |
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| COBISS.SI-ID: | 287810563 |
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| DOI: | 10.18690/analipazu.16.1-2.21-34.2026 |
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| Publication date in DKUM: | 18.08.2026 |
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| Views: | 177 |
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| Downloads: | 5 |
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| Metadata: |    |
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| Categories: | Misc.
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