| Title: | Regulation of irregular neuronal firing by autaptic transmission |
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| Authors: | ID Guo, Daqing (Author)
ID Wu, Shengdun (Author)
ID Chen, Mingming (Author)
ID Perc, Matjaž (Author)
ID Zhang, Yangsong (Author)
ID Ma, Jingling (Author)
ID Cui, Yan (Author)
ID Xu, Peng (Author)
ID Xia, Yang (Author)
ID Yao, Dezhong (Author) |
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| Files: |  Scientific_Reports_2016_Guo_et_al._Regulation_of_Irregular_Neuronal_Firing_by_Autaptic_Transmission.pdf (2,65 MB)
MD5: 4CB28F503AABD37E79B6A3282E85FF3C
 http://www.nature.com/articles/srep26096
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FNM - Faculty of Natural Sciences and Mathematics
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| Abstract: | The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the modulation of irregular neuronal firing, primarily by regulating the occurrence frequency of burst firing. In particular, we find that both excitatory and electrical autapses increase the occurrence of burst firing, thus reducing neuronal firing regularity. In contrast, inhibitory autapses suppress burst firing and therefore tend to improve the regularity of neuronal firing. Importantly, we show that these findings are independent of the firing properties of individual neurons, and as such can be observed for neurons operating in different modes. Our results provide an insightful mechanistic understanding of how different types of autapses shape irregular firing at the single-neuron level, and they highlight the functional importance of autaptic self-innervation in taming and modulating neurodynamics. |
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| Keywords: | neuronal dynamics, autapse, regulation, excitation |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2016 |
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| Number of pages: | str. 1-14 |
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| Numbering: | Letn. 6 |
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| PID: | 20.500.12556/DKUM-66409  |
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| ISSN: | 2045-2322 |
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| UDC: | 53 |
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| ISSN on article: | 2045-2322 |
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| COBISS.SI-ID: | 22210568 |
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| DOI: | 10.1038/srep26096 |
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| NUK URN: | URN:SI:UM:DK:8NOX4XBV |
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| Publication date in DKUM: | 23.06.2017 |
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| Views: | 1483 |
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| Downloads: | 448 |
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| Metadata: |    |
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| Categories: | Misc.
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