| Title: | Genetic etiology of primary premature ovarian insuffiency |
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| Authors: | ID Franic Ivanisevic, Maja (Author)
ID Franić, Damir (Author)
ID Ivovic, Miomira (Author)
ID Tancic Gajic, Milina (Author)
ID Marina, Ljiljana (Author)
ID Barac, Marija (Author)
ID Vujovic, Svetlana (Author) |
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| Files: |  Acta_Clinica_Croatica_2016_Franic_et_al._Genetic_etiology_of_primary_premature_ovarian_insufficiency.pdf (85,20 KB)
MD5: E82F97F9A16B87F4013794A806D17D93
PID: 20.500.12556/dkum/4dd8c092-46a6-4644-a132-8bc25cc512ab
 https://hrcak.srce.hr/178101
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.02 - Review Article |
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| Organization: | MF - Faculty of Medicine
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| Abstract: | Primary premature ovarian insufficiency (PPOI) is characterized by hypergonadotropic amenorrhea and hypoestrogenism in women under 40 years of age. PPOI incidence is 1:10,000 in women aged 18-25, 1:1000 in women aged 25-30 and 1:100 in women aged 35-40. In 10%-28% of cases, PPOI causes primary and in 4%-18% secondary amenorrhea. The process is a consequence of accelerated oocyte atresia, diminished number of germinated cells, and central nervous system aging. Specific genes are responsible for the control of oocyte number undergoing the ovulation process and the time to cessation of the reproductive function. A positive family history of PPOI is found in 15% of women with PPOI, indicating the existing genetic etiology. Primary POI comprises genetic aberrations linked to chromosome X (monosomy, trisomy, translocation, deletion) or to autosomal chromosome. Secondary POI implies surgical removal of ovaries, chemotherapy and radiotherapy, and infections. Diagnostic criteria include follicle stimulating hormone level >40 IU/L and estradiol level <50 pmol/L. |
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| Keywords: | primary ovarian insufficiency, etiology, genetics |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2016 |
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| Number of pages: | str. 629-635 |
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| Numbering: | Letn. 55, št. 4 |
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| PID: | 20.500.12556/DKUM-70368  |
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| ISSN: | 0353-9466 |
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| UDC: | 618.1 |
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| ISSN on article: | 0353-9466 |
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| COBISS.SI-ID: | 91569409 |
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| DOI: | 10.20471/acc.2016.55.04.14 |
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| NUK URN: | URN:SI:UM:DK:DSICNX8L |
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| Publication date in DKUM: | 08.05.2018 |
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| Views: | 1383 |
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| Downloads: | 226 |
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| Metadata: |    |
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| Categories: | Misc.
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