Pospešena ateroskleroza pri bolnicah z revmatoidnim artritisom in pomen metaloproteaz ter novejših biokemičnih kazalcev

Koren Krajnc, Metka

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Title:	Pospešena ateroskleroza pri bolnicah z revmatoidnim artritisom in pomen metaloproteaz ter novejših biokemičnih kazalcev
Authors:	ID Koren Krajnc, Metka (Author) ID Pahor, Artur (Mentor) More about this mentor... ID Hojs, Radovan (Comentor)
Files:	DOK_Koren_Krajnc_Metka_2023.pdf (1,05 MB) MD5: 72233315B38C64C3BA8194FBF7824617
Language:	Slovenian
Work type:	Doctoral dissertation
Typology:	2.08 - Doctoral Dissertation
Organization:	MF - Faculty of Medicine
Abstract:	Bolniki z revmatoidnim artritisom (RA) imajo krajšo pričakovano življenjsko dobo, glavni vzrok smrti predstavljajo srčno-žilna obolenja. Povečanega tveganja ni mogoče pojasniti zgolj s klasičnimi dejavniki tveganja (debelost, povišan krvni tlak, hiperlipidemija, kajenje). Vedno več je dokazov, da bi lahko kronično vnetje povečevalo tveganje za srčno žilna obolenja. V naši prospektivni raziskavi smo 15 let opazovali 70 bolnic z RA in 40 zdravih kontrol, brez klasičnih dejavnikov tveganja, ob vključitvi so bile vse premenopavzalne. Spremljali smo klasične dejavnike tveganja, vnetne pokazatelje (sedimentacijo, C reaktivni protein), citokine (interlevkin-6 (IL-6), tumorje nekrotizirajoči faktor alfa (TNF alfa)) in adhezijske molekule (ICAM in VCAM). Prisotnost aterosklerotičnega procesa smo ocenjevali z ultrazvočno preiskavo karotidnih arterij. Preiskovanke z RA so imele enako debelino intimo medije kot zdrave kontrole, potrdili pa smo statistično višje število plakov pri bolnicah z RA, kot pri zdravih kontrolah. Med skupinama ni bilo razlik v primerjavi klasičnih dejavnikov tveganja, potrdili smo statistično pomembne razlike v neklasičnih dejavnikov tveganja. Rezultati podpirajo teorijo vnetja kot dejavnika tveganja za pospešeno aterosklerozo pri bolnicah z RA.
Keywords:	revmatoidni artritis, ateroskleroza, metaloproteainaze
Place of publishing:	Maribor
Year of publishing:	2023
PID:	20.500.12556/DKUM-81975
COBISS.SI-ID:	169566467
Publication date in DKUM:	24.10.2023
Views:	768
Downloads:	69
Metadata:
Categories:	MF
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Licences

License:	CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Link:	http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:	The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:	23.06.2022

Secondary language

Language:	English
Title:	Accelerated Atherosclerosis in Rheumatoid Arthritis Patients and the Importance of Metalloproteinases and New Biochemical Markers
Abstract:	Patients with rheumatoid arthritis (RA) have a lower life expectancy, with cardiovascular disease being the leading cause of death. The increased risk cannot be explained only by traditional risk factors (obesity, high blood pressure, hyperlipidemia, smoking). There is growing evidence that chronic inflammation may increase the risk of cardiovascular disease. In our prospective research, we followed 15 RA patients and 40 healthy controls for 15 years; at the time of enrollment all participants were premenopausal. Traditional risk factors, inflammatory markers (sedimentation (ESR), C-reactive protein), cytokines (interleukin 6 (IL-6)), tumor necrosis factor alpha (TNF-alpha) and adhesion molecules (ICAM and VCAM) were monitored. The results of a carotid artery ultrasound scan were used to detect the presence of atherosclerotic process. Subjects with RA had the same intima-media thickness as healthy controls; however, we found that RA patients had a statistically larger number of plaques compared to healthy controls. Although there were no differences between the groups when it came to traditional risk factors, we did find statistically significant variations in non-traditional risk factors. The findings support the theory that inflammation is a risk factor for accelerated atherosclerosis in RA patients.
Keywords:	rheumatoid arthritis, atherosclerosis, metalloproteinases

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