| Title: | Gut microbiome composition in patients with chronic urticaria : a review of current evidence and data |
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| Authors: | ID Kristo, Mirela (Author)
ID Lugović-Mihić, Liborija (Author)
ID Munoz, Melba (Author)
ID Rupnik, Maja (Author)
ID Mahnič, Aleksander (Author)
ID Ozretić, Petar (Author)
ID Jaganjac, Morana (Author)
ID Cesić, Diana (Author)
ID Kuna, Matea (Author) |
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| Files: |  Kristo-2023-Gut_Microbiome_Composition_in_Pati.pdf (4,12 MB)
MD5: FCEB1985959FEB567F52A27C997FCB19
 https://doi.org/10.3390/life13010152
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.02 - Review Article |
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| Organization: | MF - Faculty of Medicine
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| Abstract: | Recent studies have linked gut microorganism composition and chronic urticaria (CU); however, the underlying mechanisms responsible for this connection are unknown. Since the human immune system is in homeostasis with microbiota, and the composition of the microbiome regulates the development and function of the immune system, it is likely that an alteration of microbiota components (a dysbiosis) could influence the course of chronic spontaneous urticaria (CSU), including disease severity, patient quality of life and treatment outcome. To date, several studies have identified changes in the gut microbiota composition of patients with CSU, though only a few have exhibited metabolic abnormalities associated with gut dysbiosis. The studies on CSU patients predominantly showed that the relative abundance of beneficial bacteria was decreased (Firmicutes and Bacteroides), while that of opportunistic bacteria was increased (Enterobacteria and Proteobacteria). In addition, serum metabolome analysis revealed that gut microbiota-associated alterations in unsaturated fatty acids and the butanoate metabolism pathway may play a role in CSU. These findings are potentially associated with inflammation mediated by the imbalance of Th1/Th2/Th17 cytokines, which might contribute to CSU pathogenesis. Further research in this field could improve clinical, diagnostic, and therapeutic approaches to patients with CSU. By applying new knowledge on gut microbial communities and metabolomics, future CSU therapies could modify the microbiota composition using agents such as probiotics or other similar agents, which, in combination with current standard therapies, could hopefully lead to a reduction in symptoms and an improved quality of life for CSU patients.Recent studies have linked gut microorganism composition and chronic urticaria (CU); however, the underlying mechanisms responsible for this connection are unknown. Since the human immune system is in homeostasis with microbiota, and the composition of the microbiome regulates the development and function of the immune system, it is likely that an alteration of microbiota components (a dysbiosis) could influence the course of chronic spontaneous urticaria (CSU), including disease severity, patient quality of life and treatment outcome. To date, several studies have identified changes in the gut microbiota composition of patients with CSU, though only a few have exhibited metabolic abnormalities associated with gut dysbiosis. The studies on CSU patients predominantly showed that the relative abundance of beneficial bacteria was decreased (Firmicutes and Bacteroides), while that of opportunistic bacteria was increased (Enterobacteria and Proteobacteria). In addition, serum metabolome analysis revealed that gut microbiota-associated alterations in unsaturated fatty acids and the butanoate metabolism pathway may play a role in CSU. These findings are potentially associated with inflammation mediated by the imbalance of Th1/Th2/Th17 cytokines, which might contribute to CSU pathogenesis. Further research in this field could improve clinical, diagnostic, and therapeutic approaches to patients with CSU. By applying new knowledge on gut microbial communities and metabolomics, future CSU therapies could modify the microbiota composition using agents such as probiotics or other similar agents, which, in combination with current standard therapies, could hopefully lead to a reduction in symptoms and an improved quality of life for CSU patients. |
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| Keywords: | gut microbiome, intestinal microbiome composition, chronic spontaneous urticaria, dysbiosis, metabolome |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 10.11.2022 |
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| Article acceptance date: | 25.12.2022 |
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| Publication date: | 04.01.2023 |
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| Publisher: | MDPI |
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| Year of publishing: | 2023 |
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| Number of pages: | Str. 1-14 |
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| Numbering: | Letn. 13, Št. 1, št. članka 152 |
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| PID: | 20.500.12556/DKUM-87102  |
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| UDC: | 616.3 |
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| ISSN on article: | 2075-1729 |
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| COBISS.SI-ID: | 168492291 |
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| DOI: | 10.3390/life13010152 |
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| Publication date in DKUM: | 19.02.2024 |
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| Views: | 575 |
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| Downloads: | 35 |
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| Metadata: |    |
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| Categories: | Misc.
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