| Title: | Vial wall effect on freeze-drying speed |
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| Authors: | ID Ramšak, Matjaž (Author)
ID Hriberšek, Matjaž (Author) |
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| Files: |  1-s2.0-S0022354923005130-main.pdf (1,88 MB)
MD5: 2D065DD09A90CBC2FEA7DA7F80B6DCED
 https://www.sciencedirect.com/science/article/pii/S0022354923005130
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FS - Faculty of Mechanical Engineering
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| Abstract: | The vial wall thermal conductivity and thickness effect on freeze-drying speed is simulated. A 2D axisymmetric numerical simulation of Mannitol freeze-drying is employed using the boundary element method. The originality of the presented approach lies in the simulation of heat transfer in the vial walls as an additional computational domain in contrast to the typical methodology without a vial wall. The numerical model was validated using our measurements and the measurements from the literature. Increasing the glass vial thickness from 1 mm to 2 mm has been found as the major factor in primary drying time, increasing the gravimetrical Kv up to 20 % for all the simulated chamber pressures. The effect of thermal conductivity was simulated using a polymer and aluminium vial replacing the standard glass vial of the same thickness. The polymer vial‘s decreased Kv value is 5.6 % at a low chamber pressure of 50 mTorr, and 12.2 % at 400 mTorr, which is in excellent agreement with the experiment. Using higher conductivity materials, for example, aluminium, only 3.7 % and 2.3 % Kv increase were computed for low and high chamber pressures respectively. |
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| Keywords: | freeze-drying, lyophilization speedup, vial heat conductivity, vial wall thickness, boundary element method |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 07.08.2023 |
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| Article acceptance date: | 04.12.2023 |
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| Publication date: | 07.12.2023 |
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| Publisher: | American Chemical Society and American Pharmaceutical Association, Elsevier |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1275-1284 |
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| Numbering: | Vol. 113, iss. 5 |
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| PID: | 20.500.12556/DKUM-88334  |
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| UDC: | 536:519.6 |
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| ISSN on article: | 1520-6017 |
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| COBISS.SI-ID: | 192744451 |
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| DOI: | 10.1016/j.xphs.2023.12.005 |
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| Copyright: | © 2023 The Authors |
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| Publication date in DKUM: | 16.04.2024 |
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| Views: | 530 |
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| Downloads: | 60 |
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| Metadata: |    |
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| Categories: | Misc.
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