| Title: | Multilayer methacrylate-based wound dressing as a therapeutic tool for targeted pain relief |
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| Authors: | ID Zidarič, Tanja (Author)
ID Skok, Kristijan (Author)
ID Orthaber, Kristjan (Author)
ID Pristovnik, Matevž (Author)
ID Gradišnik, Lidija (Author)
ID Maver, Tina (Author)
ID Maver, Uroš (Author) |
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| Files: |  Zidaric-2023-Multilayer_Methacrylate-Based_Wou.pdf (1,61 MB)
MD5: 01C6E305C1E5492519547215E7897E20
 https://doi.org/10.3390/ma16062361
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | MF - Faculty of Medicine
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| Abstract: | This study presents an innovative wound dressing system that offers a highly effective therapeutic solution for treating painful wounds. By incorporating the widely used non-steroidal anti-inflammatory drug diclofenac, we have created an active wound dressing that can provide targeted pain relief with ease. The drug was embedded within a biocompatible matrix composed of polyhydroxyethyl methacrylate and polyhydroxypropyl methacrylate. The multilayer structure of the dressing, which allows for sustained drug release and an exact application, was achieved through the layer-by-layer coating technique and the inclusion of superparamagnetic iron platinum nanoparticles. The multilayered dressings’ physicochemical, structural, and morphological properties were characterised using various methods. The synergistic effect of the incorporated drug molecules and superparamagnetic nanoparticles on the surface roughness and release kinetics resulted in controlled drug release. In addition, the proposed multilayer wound dressings were found to be biocompatible with human skin fibroblasts. Our findings suggest that the developed wound dressing system can contribute to tailored therapeutic strategies for local pain relief. |
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| Keywords: | wound dressings, pain relief, superparamagnetic nanoparticles, methacrylate |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 01.03.2023 |
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| Article acceptance date: | 13.03.2023 |
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| Publication date: | 15.03.2023 |
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| Publisher: | MDPI |
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| Year of publishing: | 2023 |
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| Number of pages: | Str. 1-21 |
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| Numbering: | Letn. 16, Št. 6, št. članka 2361 |
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| PID: | 20.500.12556/DKUM-88404  |
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| UDC: | 615.4 |
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| ISSN on article: | 1996-1944 |
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| COBISS.SI-ID: | 146598147 |
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| DOI: | 10.3390/ma16062361 |
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| Publication date in DKUM: | 19.04.2024 |
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| Views: | 665 |
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| Downloads: | 489 |
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| Metadata: |    |
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| Categories: | Misc.
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