| Title: | Modeling the amino acid effect on glucagon secretion from pancreatic alpha cells |
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| Authors: | ID Zmazek, Jan (Author)
ID Grubelnik, Vladimir (Author)
ID Markovič, Rene (Author)
ID Marhl, Marko (Author) |
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| Files: |  RAZ_Zmazek_Jan_2022.pdf (1,82 MB)
MD5: B3C5A831D6A69D4C4193582455CA247E
 https://www.mdpi.com/2218-1989/12/4/348
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FNM - Faculty of Natural Sciences and Mathematics
FERI - Faculty of Electrical Engineering and Computer Science
PEF - Faculty of Education
MF - Faculty of Medicine
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| Abstract: | Type 2 Diabetes Mellitus (T2DM) is a burdensome problem in modern society, and intensive research is focused on better understanding the underlying cellular mechanisms of hormone secretion for blood glucose regulation. T2DM is a bi-hormonal disease, and in addition to 100 years of increasing knowledge about the importance of insulin, the second hormone glucagon, secreted by pancreatic alpha cells, is becoming increasingly important. We have developed a mathematical model for glucagon secretion that incorporates all major metabolic processes of glucose, fatty acids, and glutamine as the most abundant postprandial amino acid in blood. In addition, we consider cAMP signaling in alpha cells. The model predictions quantitatively estimate the relative importance of specific metabolic and signaling pathways and particularly emphasize the important role of glutamine in promoting glucagon secretion, which is in good agreement with known experimental data. |
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| Keywords: | diabetes, hormone secretion, glucose, amino acid, cAMP |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 21.03.2022 |
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| Article acceptance date: | 12.04.2022 |
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| Publication date: | 13.04.2022 |
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| Publisher: | MDPI |
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| Year of publishing: | 2022 |
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| Number of pages: | str. 1-15 |
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| Numbering: | Vol. 12, iss. 4 |
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| PID: | 20.500.12556/DKUM-88638  |
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| UDC: | 616.379-008.64 |
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| ISSN on article: | 2218-1989 |
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| COBISS.SI-ID: | 105003779 |
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| DOI: | 10.3390/metabo12040348 |
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| Publication date in DKUM: | 21.05.2024 |
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| Views: | 419 |
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| Downloads: | 27 |
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| Metadata: |    |
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| Categories: | Misc.
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