| Title: | What do stimulated beta cells have in common with cancer cells? |
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| Authors: | ID Marhl, Marko (Author) |
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| Files: |  RAZ_Marhl_Marko_2024.pdf (2,61 MB)
MD5: 7A60D95B8598390C9F261D08F35C7E27
 https://www.sciencedirect.com/science/article/pii/S0303264724001424?via%3Dihub
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | MF - Faculty of Medicine
PEF - Faculty of Education
FNM - Faculty of Natural Sciences and Mathematics
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| Abstract: | This study investigates the metabolic parallels between stimulated pancreatic beta cells and cancer cells, focusing
on glucose and glutamine metabolism. Addressing the significant public health challenges of Type 2 Diabetes
(T2D) and cancer, we aim to deepen our understanding of the mechanisms driving insulin secretion and cellular
proliferation. Our analysis of anaplerotic cycles and the role of NADPH in biosynthesis elucidates their vital
functions in both processes. Additionally, we point out that both cell types share an antioxidative response
mediated by the Nrf2 signaling pathway, glutathione synthesis, and UCP2 upregulation. Notably, UCP2 facilitates the transfer of C4 metabolites, enhancing reductive TCA cycle metabolism. Furthermore, we observe that
hypoxic responses are transient in beta cells post-stimulation but persistent in cancer cells. By synthesizing these insights, the research may suggest novel therapeutic targets for T2D, highlighting the shared metabolic strategies of stimulated beta cells and cancer cells. This comparative analysis not only illuminates the metabolic complexity of these conditions but also emphasizes the crucial role of metabolic pathways in cell function and survival, offering fresh perspectives for tackling T2D and cancer challenges. |
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| Keywords: | reductive metabolism, succinate |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 26.03.2024 |
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| Article acceptance date: | 11.06.2024 |
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| Publication date: | 12.06.2024 |
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| Year of publishing: | 2024 |
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| Number of pages: | 11 str. |
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| Numbering: | Vol. 242, [article no.] ǂ105257 |
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| PID: | 20.500.12556/DKUM-89336  |
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| UDC: | 616.379 |
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| ISSN on article: | 0303-2647 |
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| COBISS.SI-ID: | 200576771 |
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| DOI: | 10.1016/j.biosystems.2024.105257 |
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| Publication date in DKUM: | 06.08.2024 |
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| Views: | 245 |
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| Downloads: | 44 |
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| Metadata: |    |
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| Categories: | Misc.
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