| Naslov: | What do stimulated beta cells have in common with cancer cells? |
|---|
| Avtorji: | ID Marhl, Marko (Avtor) |
|---|
| Datoteke: |  RAZ_Marhl_Marko_2024.pdf (2,61 MB)
MD5: 7A60D95B8598390C9F261D08F35C7E27
 https://www.sciencedirect.com/science/article/pii/S0303264724001424?via%3Dihub
|
|---|
| Jezik: | Angleški jezik |
|---|
| Vrsta gradiva: | Članek v reviji |
|---|
| Tipologija: | 1.01 - Izvirni znanstveni članek |
|---|
| Organizacija: | MF - Medicinska fakulteta
PEF - Pedagoška fakulteta
FNM - Fakulteta za naravoslovje in matematiko
|
|---|
| Opis: | This study investigates the metabolic parallels between stimulated pancreatic beta cells and cancer cells, focusing
on glucose and glutamine metabolism. Addressing the significant public health challenges of Type 2 Diabetes
(T2D) and cancer, we aim to deepen our understanding of the mechanisms driving insulin secretion and cellular
proliferation. Our analysis of anaplerotic cycles and the role of NADPH in biosynthesis elucidates their vital
functions in both processes. Additionally, we point out that both cell types share an antioxidative response
mediated by the Nrf2 signaling pathway, glutathione synthesis, and UCP2 upregulation. Notably, UCP2 facilitates the transfer of C4 metabolites, enhancing reductive TCA cycle metabolism. Furthermore, we observe that
hypoxic responses are transient in beta cells post-stimulation but persistent in cancer cells. By synthesizing these insights, the research may suggest novel therapeutic targets for T2D, highlighting the shared metabolic strategies of stimulated beta cells and cancer cells. This comparative analysis not only illuminates the metabolic complexity of these conditions but also emphasizes the crucial role of metabolic pathways in cell function and survival, offering fresh perspectives for tackling T2D and cancer challenges. |
|---|
| Ključne besede: | reductive metabolism, succinate |
|---|
| Status publikacije: | Objavljeno |
|---|
| Verzija publikacije: | Objavljena publikacija |
|---|
| Poslano v recenzijo: | 26.03.2024 |
|---|
| Datum sprejetja članka: | 11.06.2024 |
|---|
| Datum objave: | 12.06.2024 |
|---|
| Leto izida: | 2024 |
|---|
| Št. strani: | 11 str. |
|---|
| Številčenje: | Vol. 242, [article no.] ǂ105257 |
|---|
| PID: | 20.500.12556/DKUM-89336  |
|---|
| UDK: | 616.379 |
|---|
| COBISS.SI-ID: | 200576771 |
|---|
| DOI: | 10.1016/j.biosystems.2024.105257 |
|---|
| ISSN pri članku: | 0303-2647 |
|---|
| Datum objave v DKUM: | 06.08.2024 |
|---|
| Število ogledov: | 243 |
|---|
| Število prenosov: | 44 |
|---|
| Metapodatki: |    |
|---|
| Področja: | Ostalo
|
|---|
|
:
|
Kopiraj citat |
|---|
| | | | Skupna ocena: | (0 glasov) |
|---|
| Vaša ocena: | Ocenjevanje je dovoljeno samo prijavljenim uporabnikom. |
|---|
| Objavi na: |  |
|---|
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše
podrobnosti ali sproži prenos. |
