| Title: | The efficacy of probiotics as antiviral agents for the treatment of rotavirus gastrointestinal infections in children : an updated overview of literature |
|---|
| Authors: | ID Steyer, Andrej (Author)
ID Mičetić-Turk, Dušanka (Author)
ID Fijan, Sabina (Author) |
|---|
| Files: |  Steyer-2022-The_Efficacy_of_Probiotics_as_Anti.pdf (394,77 KB)
MD5: 1B7A80CC6831F412178D5908245F520B
 https://doi.org/10.3390/microorganisms10122392
|
|---|
| Language: | English |
|---|
| Work type: | Scientific work |
|---|
| Typology: | 1.02 - Review Article |
|---|
| Organization: | MF - Faculty of Medicine
|
|---|
| Abstract: | Enteric viruses, including the rotavirus, norovirus, and adenoviruses, are the most common cause of acute gastroenteritis. The rotavirus disease is especially prevalent among children, and studies over the past decade have revealed complex interactions between rotaviruses and the gut microbiota. One way to treat and prevent dysbiosis is the use of probiotics as an antiviral agent. This review focuses on the latest scientific evidence on the antiviral properties of probiotics against rotavirus gastroenteric infections in children. A total of 19 studies exhibited a statistically significant antiviral effect of probiotics. The main probiotics that were effective were Saccharomyces cerevisiae var. boulardii, Lacticaseibacillus rhamnosus GG, and various multi-strain probiotics. The underlying mechanism of the probiotics against rotavirus gastroenteric infections in children included immune enhancement and modulation of intestinal microbiota leading to shortening of diarrhoea. However, several clinical studies also found no significant difference in the probiotic group compared to the placebo group even though well-known strains were used, thus showing the importance of correct dosage, duration of treatment, quality of probiotics and the possible influence of other factors, such as the production process of probiotics and the influence of immunisation on the effect of probiotics. Therefore, more robust, well-designed clinical studies addressing all factors are warranted. |
|---|
| Keywords: | probiotics, microbiota, rotaviruses |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Submitted for review: | 27.10.2022 |
|---|
| Article acceptance date: | 29.11.2022 |
|---|
| Publication date: | 02.12.2022 |
|---|
| Publisher: | MDPI |
|---|
| Year of publishing: | 2022 |
|---|
| Number of pages: | Str. 1-21 |
|---|
| Numbering: | Letn. 10, Št. 12, št. člnka 2392 |
|---|
| PID: | 20.500.12556/DKUM-89370  |
|---|
| UDC: | 613.292:616.3 |
|---|
| ISSN on article: | 2076-2607 |
|---|
| COBISS.SI-ID: | 135120643 |
|---|
| DOI: | 10.3390/microorganisms10122392 |
|---|
| Publication date in DKUM: | 05.07.2024 |
|---|
| Views: | 332 |
|---|
| Downloads: | 14 |
|---|
| Metadata: |    |
|---|
| Categories: | Misc.
|
|---|
|
:
|
Copy citation |
|---|
| | | | Average score: | (0 votes) |
|---|
| Your score: | Voting is allowed only for logged in users. |
|---|
| Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
