| Title: | Impact of short-term topical steroid therapy on selective laser trabeculoplasty efficacy |
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| Authors: | ID Gračner, Tomaž (Author) |
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| Files: |  Gracner-2021-Impact_of_Short-Term_Topical_Ster.pdf (391,82 KB)
MD5: 79424A9A516BE4A8749904D34447A4DB
 https://doi.org/10.3390/jcm10184249
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | MF - Faculty of Medicine
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| Abstract: | Background: To evaluate whether short-term use of topical steroid therapy affected the efficacy of selective laser trabeculoplasty (SLT) for primary open-glaucoma (POAG). Methods: 25 eyes of 25 patients, who used a drop of dexamethasone 0.1% 4 times a day for 7 days as post-laser therapy, formed the Steroid SLT group and 24 eyes of 24 patients, where no topical steroids or nonsteroidal anti-inflammatory agents as post-laser therapy were used, formed the No-steroid SLT group. Success was defined as an intraocular pressure (IOP) lowering exceeding 20% of pretreatment IOP. Results: The mean follow-up time was 21.24 months for the Steroid SLT group and 20.25 months for the No-steroid SLT group (p = 0.990). No significant difference was found between the two groups for mean pretreatment IOP (22.20 mmHg vs. 22.33 mmHg), and for mean IOP reductions during whole follow-up period. At all follow-up visits, the mean IOP reductions were smaller in the Steroid SLT group than in the No-steroid SLT group. At all follow-up visits, the mean percent IOP reduction was smaller in the Steroid SLT group than in the No-steroid SLT group, and such a difference was significant at 12 months (25.4% vs. 29.6%, p = 0.047) and 24 months (25.3% vs. 29.7%, p = 0.024). According to the Kaplan–Meier survival analysis, the 24-month success rate was 84% in the Steroid SLT group and 79.2% in the No-steroid SLT group, with no differences between the groups (p = 0.675). Conclusion: Short-term use of topical steroid therapy had no impact on the efficacy of SLT for POAG. |
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| Keywords: | selective laser trabeculoplasty, topical steroid therapy, primary open-angle glaucoma, intraocular pressure |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 24.08.2021 |
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| Article acceptance date: | 16.09.2021 |
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| Publication date: | 19.09.2021 |
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| Publisher: | MDPI |
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| Year of publishing: | 2021 |
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| Number of pages: | Str. 1-10 |
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| Numbering: | Letn. 10, Št. 18, št. članka 4249 |
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| PID: | 20.500.12556/DKUM-89863  |
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| UDC: | 617.7 |
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| ISSN on article: | 2077-0383 |
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| COBISS.SI-ID: | 82697219 |
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| DOI: | 10.3390/jcm10184249 |
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| Publication date in DKUM: | 14.08.2024 |
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| Views: | 259 |
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| Downloads: | 15 |
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| Metadata: |    |
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| Categories: | Misc.
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