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Title:
Mapping active pharmaceutical ingredients distributions in tablets using time-of-flight secondary ion mass spectrometry with multivariate curve resolution
Authors:
ID
Finšgar, Matjaž
(
Author
)
Files:
1-s2.0-S0026265X24022689-main.pdf
(3,48 MB)
MD5: 34281576CBABE136C4662136A12B5E14
Language:
English
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FKKT - Faculty of Chemistry and Chemical Engineering
Keywords:
Tof-SIMS
,
MVSA
,
MCR
,
indapamide
,
amlodipine
,
perindopril
Publication status:
Published
Publication version:
Version of Record
Submitted for review:
06.11.2024
Article acceptance date:
08.11.2024
Publication date:
10.11.2024
Publisher:
Elsevier
Year of publishing:
2024
Number of pages:
8 str.
Numbering:
Vol. 207, [article no.] 112156
PID:
20.500.12556/DKUM-91760
UDC:
544.5/.6
ISSN on article:
1095-9149
COBISS.SI-ID:
215675395
DOI:
10.1016/j.microc.2024.112156
Copyright:
© 2024 The Author
Publication date in DKUM:
03.02.2025
Views:
209
Downloads:
11
Metadata:
Categories:
Misc.
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Record is a part of a journal
Title:
Microchemical journal
Publisher:
Elsevier
ISSN:
1095-9149
COBISS.SI-ID:
23088645
Document is financed by a project
Funder:
ARIS - Slovenian Research and Innovation Agency
Project number:
P2-0118-2022
Name:
Tekstilna kemija in napredni tekstilni materiali
Funder:
ARIS - Slovenian Research and Innovation Agency
Project number:
J1-4416-2022
Name:
Razvoj visokoobčutljive elektrokemijske metode na osnovi magnetnih polimernih nanokompozitov za določanje spojin antibiotikov v sledovih v okolijskih sistemih
Licences
License:
CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:
The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Secondary language
Language:
Slovenian
Abstract:
This study introduces an advanced approach to identifying signals associated with indapamide, amlodipine, and perindopril in solid dosage form using time-of-flight secondary ion mass spectrometry (ToF-SIMS) combined with multivariate curve resolution (MCR). The primary objective was to obtain and characterize these signals through MCR factors, which then led to identifying unique signals specific to each active pharmaceutical ingredient (API). These unique signals were crucial for constructing detailed 2D and 3D images of the API distribution within the tablet. The results demonstrated that indapamide and amlodipine exhibited multiple unique peaks, while perindopril had only one. Additionally, the study revealed non-homogeneous distribution patterns of APIs and excipients, such as SiO2 and Mg stearate. This work highlights the significance of applying advanced analytical techniques such as ToF-SIMS and MCR in the pharmaceutical field to ensure consistent therapeutic efficacy through a better understanding of API distribution.
Keywords:
farmacevtske sestavine
,
masna spektrometrija
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