| Title: | Unraveling the antibiofilm activity of a new nanogold resin for dentures and epithesis |
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| Authors: | ID Ivanović, Vera (Author)
ID Popović Antić, Danica (Author)
ID Petrović, Sanja (Author)
ID Rudolf, Rebeka (Author)
ID Majerič, Peter (Author)
ID Lazarević, Miloš (Author)
ID Djordjević, Igor (Author)
ID Lazić, Vojkan (Author)
ID Radunović, Milena (Author) |
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| Files: |  pharmaceutics-14-01513.pdf (4,99 MB)
MD5: 040F88E148953BBB94B8C23C1D4C5268
 https://www.mdpi.com/1999-4923/14/7/1513
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | FS - Faculty of Mechanical Engineering
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| Abstract: | Dentures and epitheses are mostly made from poly(methyl methacrylate) (PMMA), which
does not show antimicrobial properties. They present reservoirs of microorganisms grown in
biofilms. The aim of this study is to prepare a PMMA enriched with gold nanoparticles (AuNPs)-
PMMA/AuNPs and the examination of its physical, mechanical and antimicrobial properties. The
AuNPS were synthetized from HAuCl4 using the ultrasonic spray pyrolysis method with lyophilization. The PMMA/AuNP samples were compared to PMMA samples. Density was measured by
pycnometer. Microhardness was evaluated using the Vickers hardness test. Monomicrobial biofilm
formation (Streptococcus mitis, Candida albicans, Staphylococcus aureus and Escherichia coli) was measured by colony-forming units (CFUs) and MTT test and visualized by SEM. AuNP release was
measured indirectly (the CFUs of the medium around the sample). The density and microhardness
of the PMMA/AuNPs were similar to those of the PMMA. CFU and MTT values for the biofilms
formed on the PMMA for each of the tested species were higher than those of the biofilms formed on
the PMMA/AuNPs. The CFUs of the medium around the sample were similar for both materials.
PMMA/AuNPs showed a significant reduction in the monomicrobial biofilms of all tested species.
AuNPs are not released from PMMA/AuNPs. Density, indirect measurement of residual monomer
and dentures weight were similar between PMMA and PMMA/AuNPs. Microhardness, as a measure
of the wear resistance, was also similar between tested discs. |
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| Keywords: | PMMA, gold nanoparticles (AuNPs), biofilm, antibiofilm effect |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 08.06.2022 |
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| Article acceptance date: | 18.07.2022 |
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| Publication date: | 21.07.2022 |
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| Publisher: | MDPI AG |
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| Year of publishing: | 2022 |
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| Number of pages: | 14 str. |
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| Numbering: | Vol. 14, iss. 7 (1513) |
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| PID: | 20.500.12556/DKUM-92245  |
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| UDC: | 669.2/.9 |
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| ISSN on article: | 1999-4923 |
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| COBISS.SI-ID: | 116578051 |
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| DOI: | 10.3390/pharmaceutics14071513 |
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| Copyright: | © 2022 by the authors |
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| Publication date in DKUM: | 24.03.2025 |
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| Views: | 183 |
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| Downloads: | 10 |
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| Metadata: |    |
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| Categories: | Misc.
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