| Naslov: | First insights into the antiviral activity of chitosan-based bioactive polymers towards the bacteriophage Phi6: physicochemical characterization, inactivation potential, and inhibitory mechanisms |
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| Avtorji: | ID Plohl, Olivija (Avtor)
ID Fric, Katja (Avtor)
ID Filipić, Arijana (Avtor)
ID Kogovšek, Polona (Avtor)
ID Tušek-Žnidarič, Magda (Avtor)
ID Fras Zemljič, Lidija (Avtor) |
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| Datoteke: |  polymers-14-03357.pdf (4,27 MB)
MD5: 45DC48B140C5523CD850B5680789783E
 https://www.mdpi.com/2073-4360/14/16/3357
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Članek v reviji |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | FS - Fakulteta za strojništvo
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| Opis: | The outbreak of the worrisome coronavirus disease in 2019 has caused great concern
among the global public, especially regarding the need for personal protective equipment with
applied antiviral agents to reduce the spread and transmission of the virus. Thus, in our research,
chitosan-based bioactive polymers as potential antiviral agents were first evaluated as colloidal
macromolecular solutions by elemental analysis and charge. Three different types of low and high
molecular weight chitosan (LMW Ch, HMW Ch) and a LMW Ch derivative, i.e., quaternary chitosan
(quart-LMW Ch), were used. To explore their antiviral activity for subsequent use in the form of
coatings, the macromolecular Chs dispersions were incubated with the model virus phi6 (surrogate
for SARS-CoV-2), and the success of virus inactivation was determined. Inactivation of phi6 with
some chitosan-based compounds was very successful (>6 log), and the mechanisms behind this
were explored. The changes in viral morphology after incubation were observed and the changes in
infrared bands position were determined. In addition, dynamic and electrophoretic light scattering
studies were performed to better understand the interaction between Chs and phi6. The results
allowed us to better understand the antiviral mode of action of Chs agents as a function of their
physicochemical properties. |
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| Ključne besede: | bacteriophage phi6, bioactive polysaccharide biomaterials, chitosans, antiviral activity, dynamic and electrokinetic light scattering, charge, biointerfaces |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 20.07.2022 |
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| Datum sprejetja članka: | 11.08.2022 |
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| Datum objave: | 17.08.2022 |
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| Založnik: | MDPI AG |
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| Leto izida: | 2022 |
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| Št. strani: | str. 1-19 |
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| Številčenje: | Vol. 14, iss. 16 (3357) |
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| PID: | 20.500.12556/DKUM-92260  |
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| UDK: | 677.017:577 |
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| COBISS.SI-ID: | 119204867 |
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| DOI: | 10.3390/polym14163357 |
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| ISSN pri članku: | 2073-4360 |
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| Avtorske pravice: | © 2022 by the authors |
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| Datum objave v DKUM: | 26.03.2025 |
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| Število ogledov: | 144 |
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| Število prenosov: | 8 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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