| Title: | Addressing the needs of the rapidly aging society through the development of multifunctional bioactive coatings for orthopedic applications |
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| Authors: | ID Mastnak, Tinkara (Author)
ID Maver, Uroš (Author)
ID Finšgar, Matjaž (Author) |
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| Files: |  ijms-23-02786-v2.pdf (21,61 MB)
MD5: 36012842967AD70A60B7B11E2EC5AD31
 https://www.mdpi.com/1422-0067/23/5/2786
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| Language: | English |
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| Work type: | Article |
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| Typology: | 1.02 - Review Article |
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| Organization: | FKKT - Faculty of Chemistry and Chemical Engineering
MF - Faculty of Medicine
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| Abstract: | The unprecedented aging of the world’s population will boost the need for orthopedic
implants and expose their current limitations to a greater extent due to the medical complexity of
elderly patients and longer indwelling times of the implanted materials. Biocompatible metals with
multifunctional bioactive coatings promise to provide the means for the controlled and tailorable
release of different medications for patient-specific treatment while prolonging the material’s lifespan
and thus improving the surgical outcome. The objective of this work is to provide a review of several
groups of biocompatible materials that might be utilized as constituents for the development of
multifunctional bioactive coatings on metal materials with a focus on antimicrobial, pain-relieving,
and anticoagulant properties. Moreover, the review presents a summary of medications used in
clinical settings, the disadvantages of the commercially available products, and insight into the latest
development strategies. For a more successful translation of such research into clinical practice, extensive knowledge of the chemical interactions between the components and a detailed understanding
of the properties and mechanisms of biological matter are required. Moreover, the cost-efficiency of
the surface treatment should be considered in the development process. |
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| Keywords: | biomaterials, orthopedic implants, multifunctional coatings, drug delivery, antimicrobial, pain relief |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 15.02.2022 |
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| Article acceptance date: | 28.02.2022 |
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| Publication date: | 03.03.2022 |
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| Publisher: | MDPI |
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| Year of publishing: | 2022 |
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| Number of pages: | 35 str. |
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| Numbering: | Vol. 23, no. 5 |
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| PID: | 20.500.12556/DKUM-92446  |
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| UDC: | 577 |
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| ISSN on article: | 1422-0067 |
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| COBISS.SI-ID: | 99561219 |
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| DOI: | 10.3390/ijms23052786 |
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| Copyright: | © 2022 by the authors |
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| Publication date in DKUM: | 09.04.2025 |
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| Views: | 218 |
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| Downloads: | 11 |
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| Metadata: |    |
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| Categories: | Misc.
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